ObjectiveTo investigate the therapeutic effects of Shenfu injection in the acute renal injury and other organs injury induced by sepsis.

MethodsSeventy-two patients with sepsis were randomly divided into the control group and observation group (36 cases each group).The control group was treated with routine method, and the observation group was treated with Shenfu injection combined with conventional method.The changes of the serum levels of creatinine, blood urea nitrogen and cystatin C in two groups between before and after treatment, and other organ damage and death between two groups were compared.

ResultsThe differences of the levels of serum creatinine, blood urea nitrogen and cystatin C between two groups before treatment were not statistically significant (P>0.05), which were significantly higher than those after treatment, and the levels of serum creatinine, blood urea nitrogen and cystatin C in observation group after treatment were significantly lower than those in control group (P < 0.01).The differences the levels of serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, creatine kinase and brain natriuretic peptide between two groups before treatment were not statistically significant (P>0.05), which in two groups significantly decreased after treatment, and the levels of serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, creatine kinase and brain natriuretic peptide in observation group were lower than those in control group (P < 0.01).The death rate in observation group (2.8%) was significantly lower than that in control group (22.2%) (P < 0.05), and the survival time in observation group was longer than that in control group (P < 0.05).

ConclusionsShenfu injection can effectively alleviate the acute kidney injury and other organs injury, and reduce the mortality in sepsis patients.