改良的简化MDRD方程估算肾小球滤过率与IgA肾病病理损伤相关性研究

任丽; 张从利; 潘艳; 丁梦阳; 孙俊杰

doi:10.13898/j.cnki.issn.1000-2200.2019.07.016

改良的简化MDRD方程估算肾小球滤过率与IgA肾病病理损伤相关性研究

Study on the correlation between glomerular filtration rate estimated by modified simplified MDRD equation and pathological damage caused by of IgA nephropathy

摘要

摘要:
目的探讨改良的简化MDRD方程估算肾小球滤过率（GFR）与IgA肾病病理损伤的相关性。
方法回顾分析IgA肾病病人临床、病理学资料。GFR由改良的简化MDRD方程估算（改良的简化MDRD-eGFR）。肾脏病理损伤按照Katafuchi半定量积分标准进行评分并按照Lee's分级标准。
结果随着病理学损伤加重，改良的简化MDRD-eGFR水平逐渐降低（P < 0.05）；Katafuchi积分、肾小球硬化、肾小管间质损伤及肾血管病变与改良的简化MDRD-eGFR均存在相关性（P < 0.01）。当改良的简化MDRD-eGFR≥90 mL·min^-1·1.73 m^-2时，此种相关性消失，但病人均存在一定程度病理损伤。
结论改良的简化MDRD方程估算肾小球滤过率与IgA肾病肾脏病理损伤情况关系密切，当其 < 90 mL·min^-1·1.73 m^-2对肾小管间质损伤情况的评估预测价值较大。

Abstract:
ObjectiveTo investigate the correlation between glomerular filtration rate estimated by modified simplified MDRD equation(MDRD-eGFR) and pathological damage caused by IgA nephropathy.
MethodsThe clinical and pathological data and modified simplified MDRD-eGFR in patients with IgA nephropathy were retrospectively analyzed.The renal pathological injury was graded according to Katafuchi semi-quantitative score standard and Lee's grading standard.
ResultsWith the aggravation of pathological injury, the level of modified simplified MDRD-eGFR decreased gradually(P < 0.05).The Katafuchi score, glomerulosclerosis, tubular interstitial injury and renal vasculopathy were correlated with modified simplified MDRD-eGFR(P < 0.01).When the modified simplified MDRD-eGFR was more than or equal to 90 mL·min^-1·1.73 m^-2, the correlation disappeared, but the patients had some degree of pathological injury.
ConclusionsThe modified simplified MDRD-eGFR is closely related to the renal pathological damage in IgA nephropathy.When the modified simplified MDRD-eGFR is less than 90 mL·min^-1·1.73 m^-2, the prediction value of which in renal tubulointerstitial injury is great.

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