血细胞分析参数与子痫前期的相关性分析

王璐; 李睿; 黄新明; 张松涛

doi:10.13898/j.cnki.issn.1000-2200.2019.07.027

血细胞分析参数与子痫前期的相关性分析

Correlation analysis between blood cell parameters and preeclampsia

摘要

摘要:
目的分析探讨中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、红细胞分布宽度变异系数（RDW-CV）、平均血小板体积（MPV）在正常妊娠与子痫前期间的相关性，及MPV在子痫前期中的诊断价值。
方法选取轻度子痫前期34例、重度子痫前期57例及同期正常妊娠孕妇54名（对照组），空腹抽取静脉血，进行全血细胞分析，比较NLR、PLR、RDW-CV、血小板分布宽度（PDW）、MPV。
结果对照组与轻度子痫前期组及重度子痫前期组的MPV水平差异均具有统计学意义（P < 0.05）。对照组年龄、中性粒细胞计数（N）、淋巴细胞计数、PDW、MPV水平与子痫前期组相比差异具有统计学意义（P < 0.05~P < 0.01）。轻度子痫前期组与重度子痫前期之间N差异具有统计学意义（P < 0.05），MPV水平无差异。MPV=10.35时诊断子痫前期的敏感度为68.5%，特异度为87.0%。
结论MPV与子痫前期的发生密切相关，是诊断子痫前期的有效标志物。

Abstract:
ObjectiveTo investigate the correlation of neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), coefficient of variation of erythrocyte distribution width(RDW-CV) and mean platelet volume(MPV) between normal pregnancy and preeclampsia, and diagnostic value of MPV in preeclampsia.
MethodsThe whole blood cell in 34 pregnant women with mild preeclampsia, 57 pregnant women with severe preeclampsia and 54 normal pregnant women(control group) were analyzed.The NLR, PLR, RDW-CV, distribution width of platelet(PDW) and MPV among all patients were analyzed.
ResultsThe differences of the levels of MPV among control group, mild preeclampsia group and severe preeclampsia group were statistically significant(P < 0.05).The differences of the age, neutrophil count, lymphocyte count, PDW and MPV between the control group and preeclampsia group were statistically significant(P < 0.05 to P < 0.01).The difference of neutrophil count between mild preeclampsia group and severe preeclampsia group was statistically significant(P < 0.05).The sensitivity and specificity of MPV=10.35 was 68.5% and 87.0%, respectively.
ConclusionsMPV is closely correlated with to the occurrence of preeclampsia, and an effective marker for diagnosis of preeclampsia.

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