经直肠超声导入前列腺治疗仪联合左氧氟沙星治疗前列腺炎的临床研究

杨青松; 胡月鹏; 陶春杰; 郭美荣; 李辰; 杜靖

doi:10.13898/j.cnki.issn.1000-2200.2019.08.014

经直肠超声导入前列腺治疗仪联合左氧氟沙星治疗前列腺炎的临床研究

Study on the clinical effect of transrectal ultrasound-guided prostate therapy device combined with levofloxacin in the treatment of prostatitis

摘要

摘要:
目的分析经直肠超声导入前列腺治疗仪联合左氧氟沙星治疗前列腺炎的临床效果。
方法选取190例前列腺炎病人，随机分组2组，每组95例，对照组予以左氧氟沙星静脉滴注治疗，观察组予以经直肠前列腺治疗仪+左氧氟沙星直肠导入治疗，比较2组治愈率、总有效率、复发率、治疗前后慢性前列腺炎症状（NIH-CPSI）评分、最大尿流率（MFR）、平均尿流率（AFR）、分泌型免疫球蛋白A（SIgA）、巨噬细胞炎性蛋白1α（MIP-1α）、巨噬细胞炎性蛋白-2（MIP-2）、白细胞介素-2（IL-2）、IL-6、血管细胞黏附分子-1（VCAM-1）水平。
结果观察组治愈率、总有效率均明显高于对照组（P < 0.01），复发率明显低于对照组（P < 0.01）；观察组治疗后疼痛症状、排尿症状、症状严重程度、生活质量影响程度评分均明显低于对照组（P < 0.01），MFR、AFR明显高于对照组（P < 0.01）；观察组治疗后MIP-1α、MIP-2、SIgA、VCAM-1、IL-2、IL-6均明显低于对照组（P < 0.01）。
结论经直肠超声导入前列腺治疗仪联合左氧氟沙星治疗前列腺炎，能缓解病人临床症状，改善前列腺局部免疫介导的炎症反应，提高治愈率，降低复发率，疗效显著。

Abstract:
ObjectiveTo analyze the clinical effect of transrectal ultrasound-guided prostate therapy device combined with levofloxacin in the treatment of prostatitis.
MethodsA total of 190 patients with prostatitis were randomly divided into the control group(n=95) and observation group(n=95).The control group and observation group were treated with levofloxacin intravenous infusion and rectal prostate therapy device combined with levofloxacin rectal introduction, respectively.The cure rate, total effective rate and recurrence rate in two groups were analyzed.The levels of chronic prostatitis symptoms(NIH-CPSI) score, maximum urine flow rate(MFR), and average urine flow rate(AFR), secretory immunoglobulin A(SIgA), macrophage inflammatory protein 1α(MIP-1α), macrophage inflammatory protein-2(MIP-2), interleukin-2(IL-2), IL-6 and vascular cell adhesion molecule-1(VCAM-1) between two groups before and after treatment were compared.
ResultsThe cure rate and total effective rate in observation group were significantly higher than those in control group(P < 0.01), and the recurrence rate in observation group was significantly lower than that in control group(P < 0.01).After treatment, the scores of pain symptoms, urinary symptoms, symptom severity and quality of life in observation group were significantly lower than those in control group(P < 0.01), and the levels of MFR and AFR in observation group were significantly higher than in control group(P < 0.01).After treatment, the levels of MIP-1α, MIP-2, SIgA, VCAM-1, IL-2 and IL-6 in observation group were significantly lower than those in control group(P < 0.01).
ConclusionsTransrectal ultrasound-guided prostate therapy combined with levofloxacin in the treatment of prostatitis can alleviate the clinical symptoms, improve the local immune-mediated inflammatory response of prostate, improve the cure rate, and reduce the recurrence rate.

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