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    双歧杆菌对2型糖尿病大鼠血浆酪酪肽和胰岛素抵抗的影响

    Effect of bifidobacterium on plasma level of peptide YY and insulin resistance in type 2 diabetic rats

      摘要
    • 摘要:
      目的观察双歧杆菌对2型糖尿病（T2DM）大鼠血浆酪酪肽（PYY）和胰岛素抵抗指数（HOMA-IR）的影响。
      方法30只周龄为9周SD雄性大鼠链脲佐菌素（STZ）造模后，根据双歧杆菌灌胃剂量分成4组：正常对照组（N组）、糖尿病组（T2DM组）、高剂量组和低剂量组，双歧杆菌连续灌胃6周后，测所有大鼠空腹血糖（FBS），处死后取血浆检测PYY、糖化血红蛋白（HbA1c）、空腹胰岛素（FINS）、血脂，计算HOMA-IR，比较4组大鼠上述指标的差异。
      结果高剂量组和低剂量组HbA1c、FBS、FINS、HOMA-IR和三酰甘油低于T2DM组（P < 0.01），但高于N组（P < 0.05~P < 0.01）；高剂量组和低剂量组PYY高于T2DM组（P < 0.01），但低于N组（P < 0.01），高剂量组和低剂量组上述指标差异均无统计学意义（P>0.05），PYY和HOMA-IR呈负相关（r=-0.783，P < 0.01）。
      结论双歧杆菌可以降低T2DM大鼠HbA1c、FBS、FINS、TG和HOMA-IR，升高PYY。

       

      Abstract:
      ObjectiveTo observe the effects of bifidobacterium on the plasma level of peptide YY (YY) and HOMA-IR in type 2 diabetic(T2DM) rats.
      MethodsThirty SD male STZ model rats aged 9 weeks were divided into the normal control group(group N), diabetes mellitus group(group T2DM), high dose group and low dose group according to the gavage dose of bifidobacteria.After 6 weeks of continuous bifidobacterium administration, the levels of fasting blood sugar(FBS) were measured in all rats.The serum levels of PYY, HbA1c, fasting insulin(FINS) and blood lipids in four groups were measured after death, the HOMA-IR was calculated to compare the differences of the above indexes among four groups.
      ResultsThe levels of HbA1c, FBS, FINS, HOMA-IR and triglyceride in high-dose group and low-dose group were significantly lower than those in group T2DM(P < 0.01), and higher than those in group N(P < 0.05 to P < 0.01).The serum levels of PYY in high-dose group and low-dose group were significantly higher than that in group T2DM(P < 0.01), but lower than that in group N(P < 0.01).The differences of the above indictors between high-dose group and low-dose group were not statistically significant(P>0.05), and the level of PYY was negatively correlated with HOMA-IR(r=-0.783, P < 0.01).
      ConclusionsBifidobacterium can decrease the levels of HbA1c, FBS, FINS, TG and HOMA-IR, and increase the level of PYY in T2DM rats.

       

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