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    丁秀秀, 黄琳惠, 蔡兴俊, 黄奕江. 大剂量盐酸氨溴索注射液对肺癌病人术后肺功能恢复的效果[J]. 蚌埠医科大学学报, 2019, 44(10): 1316-1318, 1321. DOI: 10.13898/j.cnki.issn.1000-2200.2019.10.006
    引用本文: 丁秀秀, 黄琳惠, 蔡兴俊, 黄奕江. 大剂量盐酸氨溴索注射液对肺癌病人术后肺功能恢复的效果[J]. 蚌埠医科大学学报, 2019, 44(10): 1316-1318, 1321. DOI: 10.13898/j.cnki.issn.1000-2200.2019.10.006
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    DING Xiu-xiu, HUANG Lin-hui, CAI Xing-jun, HUANG Yi-jiang. Effect of high-dose ambroxol hydrochloride injection on postoperative lung function recovery in lung cancer patients[J]. Journal of Bengbu Medical University, 2019, 44(10): 1316-1318, 1321. DOI: 10.13898/j.cnki.issn.1000-2200.2019.10.006
    Citation: DING Xiu-xiu, HUANG Lin-hui, CAI Xing-jun, HUANG Yi-jiang. Effect of high-dose ambroxol hydrochloride injection on postoperative lung function recovery in lung cancer patients[J]. Journal of Bengbu Medical University, 2019, 44(10): 1316-1318, 1321. DOI: 10.13898/j.cnki.issn.1000-2200.2019.10.006
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    大剂量盐酸氨溴索注射液对肺癌病人术后肺功能恢复的效果

    Effect of high-dose ambroxol hydrochloride injection on postoperative lung function recovery in lung cancer patients

      摘要
    • 摘要:
      目的探讨大剂量氨溴索注射液对肺癌病人术后肺功能恢复的效果。
      方法纳入90例非小细胞肺癌病人，随机分为对照组与观察组，均采用胸腔镜根治手术，对照组手术前1 d与术后5 d给予常规剂量（60 mg/d）氨溴索静滴治疗，观察组采用大剂量（500 mg/d）氨溴索静滴治疗。比较2组病人住院相关指标、手术前后肺功能及血清炎性因子水平变化以及并发症发生情况。
      结果2组术后5 d肺功能指标均明显低于术前，咳痰难易程度评分明显高于术前（P < 0.01）。观察组术后5 d PEF25明显高于对照组，咳痰难易程度评分低于对照组（P < 0.01和P < .05）。2组术后1 d血清IL-6、IL-8、CRP水平较术前明显升高，观察组术后5 d IL-6、IL-8、CRP水平均明显高于术前和低于术后1 d，观察组术后1 d、5 d组IL-6、IL-8、CRP水平均明显低于对照组（P < 0.01）。观察组住院时间、抗菌药物使用时间均明显低于对照组（P < 0.01）。2组并发症发生率差异无统计学意义（P>0.05）。
      结论围手术期大剂量氨溴索能降低肺癌根治术病人肺损伤，促进肺功能的恢复，改善术后炎症反应，降低抗菌药物使用时间。

       

      Abstract:
      ObjectiveTo explore the therapeutic effects of high-dose ambroxol hydrochloride injection on postoperative lung function recovery in patients with lung cancer.
      MethodsNinety patients with non-small-cell lung cancer(NSCLC) were randomly divided into the control group and observation group according to the digital table method.All patients were treated with thoracoscopic radical surgery.Before 1 day and after 5 days of operation, the control group and observation group were intravenously treated with the conventional dose of ambroxol(60 mg/d) and high-dose ambroxol(500 mg/d), respectively.The hospital-related indicators, lung function and serum levels of inflammatory factors before and after surgery, and complications were compared between two groups.
      ResultsThe postoperative pulmonary function indexes and score of expectoration degree of two groups after operation were significantly lower and higher than those before operation, respectively(P < 0.01).The PEF25 level and score of expectoration degree in observation group after 5 days of operation were significantly higher and lower than those in control group(P < 0.01 and P < 0.05).The serum levels of IL-6, IL-8 and CRP in two groups after 1 day of operation significantly increased compared with before operation, the serum levels of IL-6, IL-8 and CRP in observation group after 5 days of operation were significantly higher and lower than those before operation and after 1 day of operation, respectively, and the serum levels of IL-6, IL-8 and CRP in observation group after 1 day and 5 days of operation were significantly lower than those in control group(P < 0.01).The hospitalization time and antibacterial use time in observation group were significantly lower than those in control group(P < 0.01).There was no statistical significance in incidence rate of complications between two groups(P < 0.05).
      ConclusionsThe perioperative application of high-dose ambroxol can reduce lung injury, promote recovery of lung function, improve postoperative inflammatory response, and reduce antibacterial use time in patients with radical lung cancer.

       

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