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    于彬. 子宫肌瘤病人血清IGF-Ⅰ、IGF-Ⅱ水平及其与Ki-67、EGFR表达的相关性分析[J]. 蚌埠医科大学学报, 2019, 44(10): 1322-1324, 1328. DOI: 10.13898/j.cnki.issn.1000-2200.2019.10.008
    引用本文: 于彬. 子宫肌瘤病人血清IGF-Ⅰ、IGF-Ⅱ水平及其与Ki-67、EGFR表达的相关性分析[J]. 蚌埠医科大学学报, 2019, 44(10): 1322-1324, 1328. DOI: 10.13898/j.cnki.issn.1000-2200.2019.10.008
    shu
    YU Bin. Correlation analysis of the serum levels of IGF-Ⅰ and IGF-Ⅱ with Ki-67 and EGFR expression in patients with uterine leiomyoma[J]. Journal of Bengbu Medical University, 2019, 44(10): 1322-1324, 1328. DOI: 10.13898/j.cnki.issn.1000-2200.2019.10.008
    Citation: YU Bin. Correlation analysis of the serum levels of IGF-Ⅰ and IGF-Ⅱ with Ki-67 and EGFR expression in patients with uterine leiomyoma[J]. Journal of Bengbu Medical University, 2019, 44(10): 1322-1324, 1328. DOI: 10.13898/j.cnki.issn.1000-2200.2019.10.008
    shu

    子宫肌瘤病人血清IGF-Ⅰ、IGF-Ⅱ水平及其与Ki-67、EGFR表达的相关性分析

    Correlation analysis of the serum levels of IGF-Ⅰ and IGF-Ⅱ with Ki-67 and EGFR expression in patients with uterine leiomyoma

      摘要
    • 摘要:
      目的研究子宫肌瘤病人血清中胰岛素生长因子（IGF）-Ⅰ、IGF-Ⅱ水平与自身组织中细胞核增殖相关抗原（Ki-67）、表皮生长因子受体（EGFR）的相关性。
      方法选取93例子宫肌瘤病人为观察组，另选同期收治的子宫腺肌病90例作为对照组，其子宫内膜组织不受疾病的影响，检测2组病人外周血中IGF-Ⅰ、IGF-Ⅱ表达情况，对子宫组织中Ki-67、EGFR指标表达情况进行观察记录，并对IGF-Ⅰ、IGF-Ⅱ水平与Ki-67、EGFR指标相关性进行分析。
      结果观察组IGF-Ⅰ、IGF-Ⅱ水平及Ki-67、EGFR阳性率显著高于对照组（P < 0.01）；观察组Ki-67阳性、EGFR阳性病人IGF-Ⅰ、IGF-Ⅱ水平显著高于Ki-67阴性、EGFR阴性者（P < 0.01）；相关性分析显示，IGF-Ⅰ、IGF-Ⅱ与Ki-67、EGFR呈显著正相关（P < 0.01）。
      结论子宫肌瘤病人血清中IGF-Ⅰ、IGF-Ⅱ指标与自身病灶组织处Ki-67、EGFR指标具有显著相关关系。

       

      Abstract:
      ObjectiveTo investigate the correlations between the serum levels of insulin growth factor-Ⅰ and Ⅱ(IGF-Ⅰ, IGF-Ⅱ), and expression levels of nuclear proliferation-related antigen(Ki-67) and epidermal growth factor receptor(EGFR) in patients with uterine leiomyoma.
      MethodsNinety-three patients with uterine leiomyoma and 90 patients with adenomyosis were divided into the observation group and control group, respectively.The serum levels of IGF-Ⅰ and IGF-Ⅱ, and expression levels of Ki-67 and EGFR in uterine tissue in two groups were recorded.The correlations between the serum levels of IGF-Ⅰ and IGF-Ⅱ, and expression levels of Ki-67 and EGFR were analyzed.
      ResultsThe serum levels of IGF-Ⅰ and IGF-Ⅱ, and positive rates of Ki-67 and EGFR in observation group were significantly higher than those in control group(P < 0.01).In the observation group, the serum levels of IGF-Ⅰ and IGF-Ⅱ in patients with positive Ki-67 and EGFR expression were significantly higher than those in patients with negative Ki-67 and EGFR expression(P < 0.01).The results of the correlation analysis showed that the serum levels of IGF-Ⅰ and IGF-Ⅱ were significantly positively correlated with Ki-67 and EGFR expression(P < 0.01).
      ConclusionsThere is a significant correlation between serum levels of IGF-Ⅰ and IGF-Ⅱ, and expression levels of Ki-67 and EGFR in cancer tissue of patients with uterine leiomyoma.

       

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