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    丁苯酞联合不同剂量阿托伐他汀对ICVD病人动脉介入治疗后血流动力学的影响

    Effect of butylphthalide combined with different doses of atorvastatin on hemodynamics in ischemic cerebrovascular disease patients treated with arterial intervention

      摘要
    • 摘要:
      目的分析丁苯酞联合不同剂量阿托伐他汀对缺血性脑血管疾病（ICVD）病人动脉介入治疗后血流动力学及氧代谢、炎症和凝血因子等的影响。
      方法选取ICVD病人180例，按照随机数字表法分为高剂量组、低剂量组和对照组，各60例。均行动脉介入治疗后常规治疗，给予丁苯酞口服。高剂量组加用20 mg阿托伐他汀口服，每天1次；低剂量组加用10 mg阿托伐他汀口服，每天1次；对照组不加用阿托伐他汀。比较3组病人血流动力学、氧代谢、炎症因子和凝血因子指标，以及治疗9个月后ICVD复发情况。
      结果与术后次日比较，3组病人术后14 d的血流动力学、氧代谢、炎症因子和凝血因子指标均有不同程度改善（P < 0.05~P < 0.01），且高剂量组病人以上各项指标均优于低剂量组和对照组（P < 0.05~P < 0.01），低剂量组亦明显优于对照组（P < 0.01）。3组病人不良反应发生率差异无统计学意义（P>0.05）。术后随访9个月，高剂量组ICVD复发率均高于低剂量组和对照组（P < 0.05和P < 0.01），而低剂量组和对照组ICVD复发率差异无统计学意义（P>0.05）。
      结论丁苯酞联合阿托伐他汀对ICVD病人动脉介入后血流动力学及氧代谢、炎症和凝血因子等功能的改善具有积极意义，20 mg阿托伐他汀长期口服可在保证安全性的前提下获得更为理想的改善效果，进一步降低ICVD复发风险。

       

      Abstract:
      ObjectiveTo analyze the effects of butylphthalide combined with different doses of atorvastatin on the hemodynamics, oxygen metabolism, inflammation and coagulation factors in ischemic cerebrovascular disease(ICVD) patients treated with arterial intervention, and provide a reference basis for selecting atorvastatin dose.
      MethodsOne hundred and eighty patients with ICVD were randomly divided into the high-dose group, low-dose group and control group(60 cases each group).Three groups were treated with arterial intervention combined with butylphthalide capsule by oral, and the high-dose and low-dose groups were additionally treated with 20 mg and 10 mg atorvastatin by oral, once a day, respectively.The changes of hemodynamics, oxygen metabolism, inflammation and coagulation factors among three groups were compared, and the recurrence of ICVD among three groups were compared after 9 months of treatment.
      ResultsCompared with after 2 days of operation, the hemodynamics, oxygen metabolism, inflammation and coagulation factors in three groups were improved in varying degrees(P < 0.05 to P < 0.01), the above indictors in high-dose group were better than those in low-dose group and control group(P < 0.05 to P < 0.01), and which in low-dose group was better than that in control group after 14 days of operation(P < 0.01).There was no statistical significance in the incidence of adverse reactions among three groups(P>0.05).After 9 months of following up, the recurrence rate of ICVD in high-dose group was higher than that in low-dose group and control group(P < 0.05 and P < 0.01), and the difference in the recurrence rate of ICVD between low-dose group and control group was not statistically significant(P>0.05).
      ConclusionsThe combination of butylphthalide with atorvastatin has positive effects on the improvement of hemodynamics, oxygen metabolism, inflammation, coagulation factors of ICVD patients after arterial intervention.Long-term oral administration of 20 mg atorvastatin can achieve more ideal improvement effects on the premise of ensuring safety, and further reduce the risk of ICVD recurrence.

       

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