静态调强下两种布野方式放疗联合化疗对术后淋巴结阳性胃癌病人的疗效比较

杨洋

doi:10.13898/j.cnki.issn.1000-2200.2019.11.016

静态调强下两种布野方式放疗联合化疗对术后淋巴结阳性胃癌病人的疗效比较

杨洋

Comparison of the differences of postoperative lymph node positive gastric cancer patients treated with two kinds of intensity-modulated radiotherapy combined with chemotherapy

Yang YANG

摘要

摘要:
目的探讨静态调强下两种布野方式放疗联合化疗对术后淋巴结阳性胃癌治疗疗效及不良反应的差异。
方法选取术后淋巴结阳性胃癌病人29例，均进行两种不同布野方式（5野组，9野组）的静态调强放射治疗联合化疗，放化疗后继续予以辅助化疗，对比不同布野方式下治疗效果及不良反应的差异。
结果5野调强治疗联合化疗在疗效方面与9野无差异（P>0.05）；5野调强治疗在恶心呕吐，中性粒细胞减少方面发生率明显高于9野（P < 0.01）；放疗后续化疗的病人中，既往接受5野调强治疗的病人耐受性低于9野治疗（P < 0.05）。
结论胃癌病人的调强放疗过程当中，综合考虑影响因素应当尽量选择9野照射方式治疗。

Abstract:
ObjectiveTo investigate the differences of therapeutic effects and adverse reactions between two kinds of intensity-modulated radiotherapy(IMRT) combined with chemotherapy in treating postoperative lymph node-positive gastric cancer.
MethodsTwenty-nine patients with postoperative lymph node-positive gastric cancer were treated with two kinds ofIMRTcombined with chemotherapy, and the differences of therapeutic effects and adverse reactions between two kinds of methods were compared.
ResultsThere is no difference in the effecacy between 5 fietd IMRT with 5 fields combined with chemotherapy and 9 fields combined with chemotherapy(P>0.05).The incidence rates of the nausea, vomiting and neutropenia of static IMRT with 5 fields were significantly higher than those of 9 fields(P < 0.01).After chemoradiotherapy, the chemotherapeutic tolerance of patients treated with static IMRT with 5 fields was significantly lower than that of static IMRT with 9 fields(P < 0.05).
ConclusionsDuring IMRT for patients with gastric cancer, the 9-field irradiation should be selected as far as possible after considering the influencing factors.

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