ObjectiveTo explore the effects of locking plate internal fixation combined with sodium hyaluronate on postoperative knee function and comprehensive stress of tibial plateau fracture.

MethodsOne hundred cases with tibial plateau fracture were randomly divided into the observation group and control group(50 cases in each group).The control group was treated with locking plate internal fixation, and the observation group was treated with locking plate internal fixation combined with sodium hyaluronate.The knee function and comprehensive stress in two groups were evaluated.

ResultsThe weight bearing time and healing time in observation group after stitch were significantly shorter than those in control group(P < 0.01).After 1, 2, 4 weeks of operation, the knee mobility and Rasmussen score in two groups gradually increased, and which in observation group was significantly higher than that in control group(P < 0.01).At postoperative 1, 3 and 7 days, the VAS scores of knee pain in two groups reduced gradually, and which in observation group after 3 and 7 days were significantly lower than that in control group(P < 0.01).At postoperative 1, 3 and 7 days, the expression levels of pain stress(NPY, PGE2 and SP), inflammatory stress(IL-1β, TNF-α and CRP) in two groups reduced gradually, and which in observation group was significantly lower than that in control group(P < 0.01).The differences of the levels of CAT and SOD after 1 day of operation between two groups were statistically significant(P < 0.01 and P < 0.05), and the difference of the levels of CAT, total antioxidant capacity and SOD after 3 and 7 days of operation between two groups were statistically significant(P < 0.01).

ConclusionsLocking plate internal fixation combined with sodium hyaluronate treating tibial plateau fracture can reduce the knee pain and stress response and promote the knee function recovery, which is worthy of clinical application.