肿瘤间质比在乳腺癌预后评估中的价值研究

单宏杰; 肖迎利; 马骖; 谢长华; 封杨; 夏艳

doi:10.13898/j.cnki.issn.1000-2200.2019.12.015

肿瘤间质比在乳腺癌预后评估中的价值研究

Value of tumor-stroma ratio in the prediction of the prognosis of breast cancer

摘要

摘要:
目的了解肿瘤间质比（TSR）在乳腺癌预后的评估作用及其与临床病理关系。
方法收集120例乳腺癌病人肿瘤组织标本经HE染色后在显微镜下寻找肿瘤浸润明显区域3个视野寻找肿瘤细胞，取最高值。并随访病人的预后情况，分析TSR与乳腺癌临床病理关系及预后的关系。
结果TSR与乳腺癌的淋巴结转移（r=0.302）、组织学分级（r=0.295）具有相关性（P < 0.01）。预后的单因素和多因素分析均显示TSR是乳腺癌的独立预后因素（P < 0.01）。
结论TSR是乳腺癌的独立预后因素，且其检测具有重复性高、操作简单等优势，值得临床推广。

Abstract:
ObjectiveTo explore the value of tumor-stroma ratio(TSR) in the assessment of the prognosis of breast cancer, and its correlation with clinicopathology.
MethodsOne hundred and twenty tumor tissue samples of breast cancer patients were stained using HE, the tumor cells in three visual fields with obvious tumor infiltration were calculated to obtain the highest value under the microscope.All cases were followed up, and the relationship between TSR, and clinicopathology and prognosis of breast cancer were analyzed.
ResultsThe TSR was correlated with the lymph node metastasis and histological grade(P < 0.01).The single and multivariate analysis of prognosis showed that the TSR was an independent prognostic factor of breast cancer(P < 0.01).
ConclusionsThe TSR is an independent prognostic factor of breast cancer, which has high repeatability and simple operation, and is worthy of clinical promotion.

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