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    刘杜先, 刘兰侠, 张杰东. GPC-3、CD10、CD147、CD138免疫组织化学联合检测对于高分化肝细胞癌与异型增生的鉴别诊断价值[J]. 蚌埠医科大学学报, 2019, 44(12): 1660-1663. DOI: 10.13898/j.cnki.issn.1000-2200.2019.12.022
    引用本文: 刘杜先, 刘兰侠, 张杰东. GPC-3、CD10、CD147、CD138免疫组织化学联合检测对于高分化肝细胞癌与异型增生的鉴别诊断价值[J]. 蚌埠医科大学学报, 2019, 44(12): 1660-1663. DOI: 10.13898/j.cnki.issn.1000-2200.2019.12.022
    shu
    LIU Du-xian, LIU Lan-xia, ZHANG Jie-dong. Differential diagnostic value of the combined immunohistochemistry detection of GPC-3, CD10, CD147 and CD138 in highly differentiated hepatocelluar carcinoma and dysplasia[J]. Journal of Bengbu Medical University, 2019, 44(12): 1660-1663. DOI: 10.13898/j.cnki.issn.1000-2200.2019.12.022
    Citation: LIU Du-xian, LIU Lan-xia, ZHANG Jie-dong. Differential diagnostic value of the combined immunohistochemistry detection of GPC-3, CD10, CD147 and CD138 in highly differentiated hepatocelluar carcinoma and dysplasia[J]. Journal of Bengbu Medical University, 2019, 44(12): 1660-1663. DOI: 10.13898/j.cnki.issn.1000-2200.2019.12.022
    shu

    GPC-3、CD10、CD147、CD138免疫组织化学联合检测对于高分化肝细胞癌与异型增生的鉴别诊断价值

    Differential diagnostic value of the combined immunohistochemistry detection of GPC-3, CD10, CD147 and CD138 in highly differentiated hepatocelluar carcinoma and dysplasia

      摘要
    • 摘要:
      目的探讨磷脂酰肌醇蛋白聚糖-3（GPC-3）、CD10、CD147和CD138在高分化肝细胞癌与异型增生病理鉴别诊断中的联合互补诊断价值。
      方法应用免疫组织化学法检测76例高分化肝细胞癌和癌周异型增生结节内GPC-3、CD10、CD147和CD138的表达情况并进行分析。
      结果高分化肝细胞癌组织中GPC-3、CD10、CD147较异型增生结节内高表达，且异型增生结节内表达常常杂乱不均；而CD138在异型增生结节中高表达，高分化肝细胞癌组织中弱表达或不表达。高分化肝细胞癌和异型增生结节组织内GPC-3、CD10、CD147和CD138的表达差异均有统计学意义（P < 0.01）。4种标记联合检测诊断高分化肝细胞癌的灵敏度达96.05%，而特异性仅为52.6%。
      结论GPC-3、CD10、CD147和CD138对高分化肝细胞癌与异型增生具有较高的病理鉴别诊断价值，可作为肝穿标本内两者区别的客观辅助指标。

       

      Abstract:
      ObjectiveTo investigate the differential diagnostic value of the combined immunohistochemistry detection of GPC-3, CD10, CD147 and CD138 in highly differentiated hepatocelluar carcinoma and dysplasia.
      MethodsThe levels of GPC-3, CD10, CD147 and CD138 in 76 cases with highly differentiated hepatocelluar carcinoma and peripheral dysplastic nodules were explored using immunohistochemistry, and the result of which was analyzed.
      ResultsCompared with the dysplastic nodules, the levels of GPC-3, CD10 and CD147 in highly differentiated hepatocelluar carcinoma tissue were higher, and these expressions in dysplastic nodules were often disorder and uneven.The expression levels of CD138 in dysplastic nodules and highly differentiated hepatocelluar carcinoma tissue were high and weak or no, respectively.The differences of the levels of GPC-3, CD10, CD147 and CD138 were statistically significant between highly differentiated hepatocelluar carcinoma tissue and dysplastic nodule(P < 0.01).The sensitivities of the combined detection of four markers in highly differentiated hepatocelluar carcinoma tissue and dysplastic nodule were 96.05% and 52.6%, respectively.
      ConclusionsThe pathologic differential diagnosis value of the combined detection of GPC-3, CD10, CD147 and CD138 in highly differentiated hepatocellular carcinoma and dysplasia is higher, which can be used as the objective auxiliary indicators between the two in liver biopsy specimens.

       

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