ObjectiveTo compare the serum lipid level between patients with benign breast disease and invasive breast cancer, and between positive hormone receptor (HR) and human epidermal growth factor receptor-2 (HER-2) -positive patients, and analyze the correlation between the level of lipid, and occurrence and development of breast cancer.

MethodsOne hundred patients with invasive breast cancer (including 50 cases with HR-positive and 50 cases with HER-2-positive) and 100 patients with benign breast disease were divided into the observation group and control group, respectively.The levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in two groups were detected, the relationship between the level of serum lipid and invasive breast cancer was analyzed, and the difference of the blood lipid level between HR-positive and HER-2-positive breast cancer patients was analyzed.

ResultsThe serum levels of TC, TG and LDL-C in observation group were significantly higher than those in control group (P < 0.05 to P < 0.01), and the HDL-C level in observation group was significantly lower than that in control group (P < 0.01).According to the stratified analysis of pre-menopause and post-menopause, except for the LDL-C, the differences of other indicators were statistically significant (P < 0.05).The levels of TC, TG and LDL-C in HER-2-positive breast cancer patients were significantly higher than those in HR-positive patients (P < 0.05), and the level of HDL-C in HER-2-positive breast cancer patients was significantly lower than that in HR-positive patients (P < 0.05).

ConclusionsThere is a certain correlation between serum lipid level and breast cancer risk for women.The high levels of TC, TG, LDL-C and low level of HDL-C may be related to the occurrence, development and molecular classifications of breast cancer, which suggests that the lipid analysis is a new direction of molecular classifications.