血清胱抑素C、尿酸水平与帕金森病伴认知功能障碍的相关性分析

叶明; 许娟娟; 谢静; 时鹏; 张丽娜; 刘晓林

doi:10.13898/j.cnki.issn.1000-2200.2020.02.013

血清胱抑素C、尿酸水平与帕金森病伴认知功能障碍的相关性分析

Correlation analysis of the serum levels of cystatin C and uric acid with cognitive impairment in Parkinson's disease

摘要

摘要:
目的探讨帕金森病（PD）病人血清半胱氨酸蛋白酶抑制剂C（胱抑素C）、尿酸水平的变化，并分析血清胱抑素C、尿酸水平与PD伴认知功能障碍的相关性。
方法选择60例PD病人为PD组，年龄及性别相匹配的30名健康体检者为对照组。对PD组病人行简易智力状况检查量表（MMSE）评分，根据MMSE评分将PD组分为PD伴认知功能障碍组、PD不伴认知功能障碍组。检测各组血清胱抑素C及尿酸水平。
结果PD组血清胱抑素C水平高于对照组（P < 0.05），血尿酸水平明显低于对照组（P < 0.01）。PD伴认知功能障碍组血清胱抑素C水平明显高于不伴认知功能障碍组（P < 0.01），血尿酸水平低于不伴认知功能障碍组（P < 0.05）。血清胱抑素C水平与MMSE评分呈负明显相关关系（r=-0.403，P < 0.01）；血清尿酸水平与MMSE评分呈正相关关系（r=0.286，P < 0.05）。
结论血清胱抑素C及尿酸水平与PD伴认知功能障碍有关，可作为PD伴认知功能障碍的早期生物学评估指标。

Abstract:
ObjectiveTo investigate the changes of serum levels of cystatin C and uric acid in patients with Parkinson's disease(PD), and analyze the correlation of serum levels of cystatin C and uric acid with cognitive impairment.
MethodsSixty patients with PD and 30 cases healthy examiners matched for gender and age were divided into the observation group(PD group) and control group, respectively.The PD group were subdivided into the PD complicated with cognitive impairment group and PD complicated without cognitive impairment group according to the mini-mental State Examination(MMSE) score.The serum levels of cystatin C and uric acid in all groups were measured.
ResultsThe serum levels of cystatin C and uric acid in PD group were higher and lower than those in control group, respectively(P < 0.05 and P < 0.01).The serum levels of cystatin C and uric acid in PD complicated with cognitive impairment group were higher and lower than those in PD complicated without cognitive impairment group, respectively(P < 0.01 and P < 0.05).The serum level of cystatin C was negatively correlated with MMSE score(P < 0.01), and the serum level of uric acid was positively correlated with MMSE score(P < 0.05).
ConclusionsThe serum levels of cystatin C and uric acid are correlated with PD complicated with cognitive impairment, which can be used as an early biological evaluation index in PD complicated with cognitive impairment.

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