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    SPINK1和Vimentin在非小细胞肺癌中的表达及意义

    Expression levels of SPINK1 and Vimentin in non-small cell lung cancer and its clinical significance

      摘要
    • 摘要:
      目的探讨丝氨酸蛋白酶抑制剂Kazal 1型（serine protease inhibitor Kazal 1，SPINK1）和Vimentin在非小细胞肺癌（non-small cell lung cancer，NSCLC）组织中的表达及其意义。
      方法免疫组织化学SP法检测136例NSCLC和62例正常肺组织中SPINK1和Vimentin表达，进行单因素Kaplan-Meier生存分析和多因素Cox回归分析。
      结果SPINK1、Vimentin在136例NSCLC组织中的阳性率分别为65.4%（89/136）、52.9%（72/136），在正常肺组织中的阳性表达率分别为4.8%（3/62）、3.2%（2/62），差异均有统计学意义（P < 0.01）。不同TNM分期、是否淋巴结转移病人的SPINK1和Vimentin表达阳性率差异均有统计学意义（P < 0.05~P < 0.01），不同分化程度病人SPINK1表达阳性率差异有统计学意义（P < 0.05）。NSCLC组织中SPINK1与Vimentin表达呈正相关关系（rs=0.368，P < 0.01）。多因素Cox回归分析显示，TNM分期、淋巴结转移、SPINK1及Vimentin表达水平均为NSCLC预后的独立影响因素（P < 0.05~P < 0.01）。
      结论SPINK1和Vimentin可能在NSCLC的进展、转移中扮演重要的角色，同时SPINK1可能作为预测NSCLC预后的新的标记物。

       

      Abstract:
      ObjectiveTo explore the expression levels of serine protease inhibitor Kazal 1(SPINK1) and Vimentin in non-small cell lung cancer(NSCLC) and its clinical significance.
      MethodsThe expression levels of SPINK1 and Vimentin in 136 cases of NSCLC tissue and 62 cases of normal lung tissue were detected using the immunohistochemical SP method, and the data was analyzed using univariate Kaplan-Meier survival analysis and multivariate Cox regression analysis.
      ResultsThe positive rates of SPINK1 and Vimentin expression in 136 cases of NSCLC tissue and 62 cases of normal tissues were 65.4%(89/136) and 52.9%(72/136) and 4.8%(3/62) and 3.2%(2/62), respectively, and the differences of which were statistically significant(P < 0.01).The differences of the expression levels of SPINK1 and Vimentin in NSCLC tissues with different TNM stages and lymph node metastasis were significantly significant(P < 0.05 to P < 0.01), and the difference of the expression level of SPINK1 in NSCLC tissues with different differentiation degrees was significantly significant(P < 0.05).The expression level of SPINK1 was positively correlated with Vimentin in NSCLC tissue(rs=0.368, P < 0.01).The results of multivariate Cox regression analysis showed that the TNM stage, lymph node metastasis, and expression levels of SPINK1 and Vimentin were the independent influencing factors of NSCLC prognosis(P < 0.05 to P < 0.01).
      ConclusionsSPINK1 and Vimentin possibly play a role in the development, invasion and metastasis of NSCLC, and SPINK1 may act as a new indicator in predicting the prognosis of NSCLC.

       

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