ObjectiveTo analyze the trend and risk factors of single drug-resistance in tuberculosis(TB) patients in recent years, and provide a reference for the early detection of drug-resistance tuberculosis.

MethodsThe clinical data of the TB patients from the Fuyang Infectious Disease Hospital from 2015 to 2017 were collected, the single drug-resistance trend of four kinds of first-line anti-TB drug was analyzed, and the clinical characteristics and risk factors associated with single drug-resistance were further investigated.

ResultsThe drug-resistance rates of isoniazid, rifampicin, ethambutol and streptomycin of the first-line anti-TB drugs did not increase or decrease within 3 years(P>0.05).The farmers, history of TB exposure, pulmonary cavities, bilateral lung involvement, complicated with chronic obstructive pulmonary disease and long-term hormone use could increase the risk of drug-resistance in TB patients(P < 0.05 to P < 0.01), and the concomitant diabetes was a protective factor in the development of drug-resistance TB(P < 0.01).

ConclusionsThe drug-resistance in the farmers, history of TB exposure, pulmonary cavities, bilateral lung involvement, complicated with chronic obstructive pulmonary disease and long-term hormone use patients should timely be detected, and the targeted treatment for single drug-resistance TB patients should be implemented.