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    上海市宝山区HPV基因分型的特征分析

    Analysis of the characteristics of HPV genotype in Baoshan district of Shanghai

      摘要
    • 摘要:
      目的了解上海市宝山区妇女人乳头瘤病毒（human papilloma virus，HPV）感染率及其与年龄的关系，以及各亚型的分布情况，为该地区宫颈癌防治提供依据。
      方法采用流式荧光杂交法检测7 709例女性宫颈脱落细胞27种HPV基因型，分析HPV感染的阳性率和年龄段的关系，及HPV亚型感染的分布特点。
      结果7 709例标本中HPV阳性1 237例，感染率为16.05%，27种HPV亚型均有检出。其中高危型833例，感染率为10.81%，前5位高危型阳性HPV依次为HPV52、16、53、58、39；低危型254例，感染率为3.29%，前5位低危型HPV依次为HPV61、43、55、81、6。HPV感染人群主要分布在41~50岁和31~40岁年龄组，各年龄组感染率差异有统计学意义（P < 0.01）。在1 237例HPV阳性标本中，以单基因型感染为主，双重感染次之，少数人群存在多重感染。
      结论HPV以单一高危型感染为主，常见高危型为HPV52、16、53、58、39。41~50岁为感染高峰期。宫颈癌的筛查、防治以及疫苗的开发应用需同时考虑HPV基因分型和年龄因素。

       

      Abstract:
      ObjectiveTo investigate the infection rate of human papilloma virus (HPV) among women in Baoshan district of Shanghai and its relationship with age, as well as the distribution of various subtypes, so as to provide the theoretical basis for the prevention and treatment of cervical cancer in this region.
      MethodsTwenty-seven HPV genotypes were detected by flow fluorescence hybridization in the samples of cervicalexfoliatedcells from 7 709 women.The relationship between HPV infection rate and age, and the distribution characteristics of HPV subtype infection were analyzed.
      ResultsIn the 7 709 cases, 1 237 cases were HPV-positive with the infection rate of 16.05%, and all the 27 HPV subtypes were found.Among them, 833 cases were high-risk genotype with the infection rate of 10.81%, and the top five high-risk genotypes were HPV 52, 16, 53, 58, 39;254 cases were low-risk genotype with the infection rate of 3.29%, and the top five low-risk genotypes were HPV61, 43, 55, 81, 6.HPV infection was mainly distributed in 41-50 and 31-40 years old groups, and the difference of infection rate among different age groups was statistically significant(P < 0.01).In the 1 237 cases with HPV infection, it was mainly the single genotype infection, followed by double infection, and a few multiple infection.
      ConclusionsHPV infection is mainly single high-risk genotype, and the common high-risk genotypes are HPV52, 16, 53, 58, 39.The peak age of HPV infection is between 41 and 50 years old.HPV genotype and age should be taken into account in the screening, prevention and treatment of cervical cancer as well as the development and application of vaccines.

       

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