高级检索
    左芦根, 葛思堂, 张宗兵, 朱玉可, 朱翔, 王迅, 姜从桥, 李仕青, 刘牧林. Enah在胃癌组织中的表达及临床价值研究[J]. 蚌埠医科大学学报, 2020, 45(5): 578-581. DOI: 10.13898/j.cnki.issn.1000-2200.2020.05.005
    引用本文: 左芦根, 葛思堂, 张宗兵, 朱玉可, 朱翔, 王迅, 姜从桥, 李仕青, 刘牧林. Enah在胃癌组织中的表达及临床价值研究[J]. 蚌埠医科大学学报, 2020, 45(5): 578-581. DOI: 10.13898/j.cnki.issn.1000-2200.2020.05.005
    shu
    ZUO Lu-gen, GE Si-tang, ZHANG Zong-bing, ZHU Yu-ke, ZHU Xiang, WANG Xun, JIANG Cong-qiao, LI Shi-qing, LIU Mu-lin. Study on the expression and clinical value of Enah in gastric cancer tissues[J]. Journal of Bengbu Medical University, 2020, 45(5): 578-581. DOI: 10.13898/j.cnki.issn.1000-2200.2020.05.005
    Citation: ZUO Lu-gen, GE Si-tang, ZHANG Zong-bing, ZHU Yu-ke, ZHU Xiang, WANG Xun, JIANG Cong-qiao, LI Shi-qing, LIU Mu-lin. Study on the expression and clinical value of Enah in gastric cancer tissues[J]. Journal of Bengbu Medical University, 2020, 45(5): 578-581. DOI: 10.13898/j.cnki.issn.1000-2200.2020.05.005
    shu

    Enah在胃癌组织中的表达及临床价值研究

    Study on the expression and clinical value of Enah in gastric cancer tissues

      摘要
    • 摘要:
      目的分析Enah蛋白在胃癌中的表达及临床价值，以期为胃癌的诊疗提供参考。
      方法纳入行胃癌根治术病人97例，使用免疫组化标记胃癌组织和癌旁组织内的Enah，并计算目标蛋白光密度值，分析2种组织中Enah的表达差异。以胃癌组织内Enah表达量的中位数为界，将病人分为Enah高表达组(n=48)和低表达组(n=49)，比较2组临床病理学参数及术后5年生存率。采用Cox回归模型分析Enah是否为胃癌术后5年死亡的独立危险因素。
      结果胃癌组织中Enah相对表达量高于癌旁组织(P＜0.01)。Enah高表达组在病理分级为G3~G4、T分期为3~4期、CEA≥5μg/L及CA19-9≥37kU/L的比例均高于Enah低表达组(P＜0.05)。Enah高表达组术后5年生存率明显低于Enah低表达组(P＜0.01)。Cox多元回归模型分析得出：病理分级为G3~G4、Enah高表达及CA19-9≥37kU/L是影响胃癌术后5年生存率的独立危险因素(P＜0.05～P＜0.01)。
      结论Enah在胃癌组织中呈现高表达，并与肿瘤进展相关，对预后判断具有一定价值。

       

      Abstract:
      ObjectiveTo analyze the expression and clinical value of Enah in gastric cancer tissues in order to provide reference for the diagnosis and treatment of gastric cancer.
      MethodsEnah in gastric and paracancer tissues of 97 patients treated with radical gastrectomy were stained using immunohistochemistry to calculate the target protein integrated option density(IOD) for comparing the expression differences of Enah between two tissues.All patients were divided into the high expression of Enah group(n=48) and low expression of Enah group(n=49) according to the median number of Enah expression in gastric cancer tissues.The clinical pathological parameters and 5-year survival rate were compared between two groups.The Cox regression model was used to analyze whether Enah was an independent risk factor of 5-year mortality after gastric cancer surgery.
      ResultsThe relative expression level of Enah in gastric cancer tissues was significantly higher than that in adjacent tissues(P＜0.01).The ratios of patients with pathological grades for G3-G4, T stage 3-4, CEA≥5μg/L and CA19-9≥37kU/L in high expression of Enah group were higher those in low expression of Enah group(P＜0.05).The postoperative 5-year survival rate in high expression of Enah group were significantly lower those in low expression of Enah group(P＜0.01).The results of Cox multiple regression model analysis showed that the pathological grade for G3-G4, high expression of Enah and CA19-9≥37kU/L were the independent risk factors of 5-year survival rate after gastric cancer surgery.
      ConclusionsThe expression level of Enah in gastric cancer tissues is high, which is associated with the tumor progression, and has certain diagnostic value for prognosis.

       

      • HTML全文
      • 参考文献(15)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回