晚发性抑郁症病人同型半胱氨酸水平和认知功能的研究

陈黎明; 王小泉; 王祖森

doi:10.13898/j.cnki.issn.1000-2200.2020.06.031

晚发性抑郁症病人同型半胱氨酸水平和认知功能的研究

Study on the homocysteine level and cognitive function in late-onset depression

摘要

摘要:
目的探讨晚发性抑郁症病人同型半胱氨酸（Hcy）水平与认知功能的关系。
方法采用病例对照研究方法，对98例晚发性抑郁症病人（观察组）及88名正常老年人（对照组）进行认知功能评定，所有受试者采用酶法进行血液Hcy水平测定。
结果观察组Hcy水平高于对照组（P < 0.05），各项认知功能评分均低于对照组（P < 0.01）。相关性分析显示，Hcy水平与HAMD评分无相关性（P>0.05），Hcy水平与简易智力状态检查量表总分呈负相关（P < 0.05）。
结论晚发性抑郁症病人存在Hcy水平的增高。与正常老年群体相比，晚发性抑郁症病人存在明显的注意、短时记忆、言语及执行功能等方面的认知功能缺陷。

Abstract:
ObjectiveTo study the relationship between homocysteine(Hcy) level and cognitive function in late-onset depression.
MethodsThe cognitive function in 98 patients with late-onset depression(observation group) and 88 healthy olders(control group) was detected using case-control study method, and the serum levels of Hcy in two groups were enzymatically tested.
ResultsThe Hcy level in observation group was higher than that in control group(P < 0.05).The cognitive function scores in observation group were lower than that in control group(P < 0.01).The results of correlation analysis showed that the Hcy level was not correlated with HAMD score(P>0.05), and the Hcy level was negatively correlated with the total score of MMSE(P < 0.05).
ConclusionsThe levels of Hcy in patients with late-onset depression increase.Compared with the normal elderly population, the cognitive deficits in attention, short-term memory, speech, and executive function in patients with late-onset depression are obvious.

HTML全文

参考文献(15)

施引文献

资源附件(0)