高级检索

    慢性HBV感染者血脂、血糖和尿酸水平对肝纤维化分期的影响

    Effect of the levels of blood lipid, blood glucose and uric acid on the stage of liver fibrosis in patients with chronic HBV infection

      摘要
    • 摘要:
      目的探讨慢性HBV感染者的血脂、血糖和尿酸水平对肝纤维化分期的影响。
      方法收集169例慢性乙型肝炎(CHB)病人临床资料，包括年龄、性别、血常规、肝功能、尿酸、血脂、血糖、凝血酶原时间、乙肝两对半、甲胎蛋白、HBV DNA，分析其与肝纤维化发生的相关性。
      结果纤维化分期 < S2病人总胆固醇(CHO)和低密度脂蛋白(LDL)异常发生率分别为23.91%、15.22%，均高于纤维化分期≥S2病人的9.68%、5.19%(P < 0.05)，而纤维化分期 < S2病人的高密度脂蛋白(HDL)和载脂蛋白A (APOA)异常发生率分别为10.87%、3.26%，均低于纤维化分期≥S2病人的24.68%、18.18%(P < 0.05和P < 0.01)。logistics回归分析显示谷氨酸氨基转移酶(OR=1.034，P < 0.05)、凝血酶原时间(OR=1.981，P < 0.01)、LDL (OR=0.499，P < 0.01)、APOA (OR=0.375，P < 0.05)为慢性CHB病人中、重度纤维化的独立预测因素。
      结论慢性HBV感染者的血脂水平在一定程度上能反映肝纤维化严重程度，而血糖、UA水平对肝纤维化分期无明显预测意义。

       

      Abstract:
      ObjectiveTo investigate the influence of the levels of blood lipid, blood glucose and uric acid on the stage of liver fibrosis in patients with chronic HBV infection.
      MethodsThe clinical data of 169 patients with chronic hepatitis B(CHB), which included the age, gender, blood routine examination, liver function, uric acid, blood lipid, blood glucose, prothrombin time, hepatitis B two fifty-fifty, alpha fetoprotein and HBV DNA were collected, and their correlations with the occurrence of liver fibrosis were analyzed.
      ResultsThe abnormal rates of total cholesterol(CHO) and low density lipoprotein(LDL) in patients with fibrosis stage < S2(23.91% and 15.22%) were higher than those in patients with fibrosis stage ≥S2(9.68% and 5.19%), respectively (P < 0.05), while the abnormal rates of high density lipoproterin and aplipoprotein A (APOA) in patients with fibrosis stage < S2(10.87% and 3.26%) were lower than those in patients with fibrosis stage ≥ S2(24.68% and 18.18%), respectively(P < 0.05 and P < 0.01).The results of logistic regression analysis showed that AST(OR=1.034, P < 0.05), prothrombin time (OR=1.981, P < 0.01), LDL (OR=0.499, P < 0.01), APOA(OR=0.375, P < 0.05) were the independent predictors of moderate and severe fibrosis in CHB patients.
      ConclusionsThe serum lipid level of patients with chronic HBV infection can reflect the severity of liver fibrosis to some extent, while the blood glucose and uric acid levels have no significant predictive significance for the stage of liver fibrosis.

       

      • HTML全文
      • 参考文献(12)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回