宫颈高级别病变病人HPV不同亚型分布情况

项媛媛; 王晴; 张蓓

doi:10.13898/j.cnki.issn.1000-2200.2020.10.024

宫颈高级别病变病人HPV不同亚型分布情况

Distribution of different subtypes of HPV in patients with high-grade cervical lesions

摘要

摘要:
目的探讨宫颈高级别病变病人人乳头瘤病毒（HPV）不同亚型分布情况。
方法选取110例宫颈高级别病变的病人，均行液基细胞学检查（TCT）、HPV分型检查及阴道镜活检，观察病人不同类型HPV基因型分布情况。
结果110例病人中HPV阳性91例，阳性率为82.7%。91例HPV阳性病人中，HPV基因型感染率位于前5位的分别为HPV16（28.2%）、HPV58（13.0%）、HPV52（11.4%）、HPV18（11.4%）、HPV33（10.7%）。HPV单一感染62例，多重感染29例。单一感染以HPV16、HPV18感染多见，多重感染以HPV58、HPV33、HPV16和HPV52感染多见。在CINⅡ级及CINⅢ级病人中，HPV16单一感染均最高。CINⅢ级单一感染率高于CINⅡ级（P < 0.001）。
结论随宫颈高级别病变加重，HPV16感染率增加，HPV16、HPV58、HPV18、HPV33、HPV52在宫颈高级别病变中感染率高，其检测有助于宫颈高级别病变的识别。

Abstract:
ObjectiveTo investigate the distribution of different subtypes of human papillomavirus(HPV) in patients with high-grade cervical lesions.
MethodsA total of 110 patients with high-grade cervical lesions were examined using thiprep cytology test, HPV typing and colposcopy biopsy.The distribution of different HPV genotypes in patients were observed.
ResultsAmong 110 patients, the positive HPV in 91 cases were found, and the positive rate of which was 82.7%.Among the 91 HPV-positive patients, the top 5 genotype of HPV were HPV16(28.2%), HPV58(13.0%), HPV52(11.4%), HPV18(11.4%) and HPV33(10.7%), respectively.There were 62 cases of single HPV infection and 29 cases of multiple HPV infection.HPV16 and HPV18 were more common in single infection, and HPV58, HPV33, HPV16 and HPV52 were more common in multiple infection.In CIN Ⅱ and CIN Ⅲ level patients, the single infection of HPV16 was the highest.The single infection rate of CIN Ⅲ level was higher than that of CIN Ⅱ level(P < 0.05).
ConclusionWith the aggravation of high-grade cervical lesions, the infection rate of HPV16 increases, the infection rates of HPV16, HPV58, HPV18, HPV33 and HPV52 in high-grade cervical lesions are high, and the detection of which is helpful for the recognition of high-grade cervical lesions.

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