高级检索
    王葳, 曹义娟, 马娟. 拮抗剂方案助孕hCG日雌二醇水平对妊娠结局的影响[J]. 蚌埠医科大学学报, 2020, 45(11): 1494-1497. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.011
    引用本文: 王葳, 曹义娟, 马娟. 拮抗剂方案助孕hCG日雌二醇水平对妊娠结局的影响[J]. 蚌埠医科大学学报, 2020, 45(11): 1494-1497. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.011
    shu
    WANG Wei, CAO Yi-juan, MA Juan. Effect of estradiol level on pregnancy outcome on the hCG day of antagonist protocol[J]. Journal of Bengbu Medical University, 2020, 45(11): 1494-1497. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.011
    Citation: WANG Wei, CAO Yi-juan, MA Juan. Effect of estradiol level on pregnancy outcome on the hCG day of antagonist protocol[J]. Journal of Bengbu Medical University, 2020, 45(11): 1494-1497. DOI: 10.13898/j.cnki.issn.1000-2200.2020.11.011
    shu

    拮抗剂方案助孕hCG日雌二醇水平对妊娠结局的影响

    Effect of estradiol level on pregnancy outcome on the hCG day of antagonist protocol

      摘要
    • 摘要:
      目的探讨拮抗剂方案人绒毛膜促性腺激素（hCG）日血清雌二醇（E2）水平对新鲜胚胎移植周期妊娠结局的影响。
      方法回顾性分析行体外受精-胚胎移植/卵胞浆内单精子注射（IVF/ICSI）拮抗剂方案助孕共216个周期病人的临床资料。根据hCG日E2水平将其分为4组：A组 < 1 600 pg/mL，B组1 600~3 200 pg/mL，C组>3 200~4 800 pg/mL，D组>4 800 pg/mL。比较各组获卵数、单个卵泡E2水平、获胚胎数、受精率、卵裂率、优质胚胎率、胚胎种植率、临床妊娠率和早期流产率。
      结果B、C、D组获卵数、获胚胎数较A组高，C、D组较B组高，D组较C组高（P < 0.05）。C、D组单个卵泡E2水平较A组高，D组较B组高（P < 0.05）。D组胚胎种植率较B、C组低（P < 0.05），4组受精率、卵裂率、优质胚胎率、临床妊娠率及早期流产率差异均无统计学意义（P>0.05）。
      结论拮抗剂方案中高E2水平病人获卵数及获胚胎数增多，优质胚胎率不会受到影响，但鲜胚移植胚胎种植率降低。

       

      Abstract:
      ObjectiveTo investigate the effect of estradiol (E2) level on the human chorionic gonadotropin(hCG)day of antagonist protocol on the pregnancy outcome of fresh embryo transfer cycle.
      MethodsThe clinical data of 216 cycles of in vitro fertilization and embryo transfer/intra cytoplasmic sperm injection (IVF/ICSI) antagonist protocol were retrospectively analyzed.According to the E2 level on hCG day, the patients were divided into group A (< 1 600 pg/mL), group B (1 600-3 200 pg/mL), group C (>3 200-4 800 pg/mL), and group D (>4 800 pg/mL).The number of obtained oocytes, E2 level of single follicle, number of obtained embryos, fertilization rate, cleavage rate, high-quality embryo rate, embryo implantation rate, clinical pregnancy rate and early abortion rate were compared between the two groups.
      ResultsThe number of obtained oocytes and obtained embryos in group B, group C and group D was higher than that in group A, which in group C and group D was higher than that in group B, and which in group D was higher than that in group C(P < 0.05).The E2 level of single follicle in group C and group D was higher than that in group A, which in group D was higher than that in group B (P < 0.05).The embryo implantation rate in group D was lower than that in group B and group C (P < 0.05).There was no statistical difference in fertilization rate, cleavage rate, high-quality embryo rate, clinical pregnancy rate and early abortion rate among the four groups (P>0.05).
      ConclusionsIn the antagonist protocol, the number of obtained oocytes and embryos in patients with high E2 level increases, and the rate of high-quality embryos is not affected, but the implantation rate of fresh embryo transfer decreases.

       

      • HTML全文
      • 参考文献(13)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回