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    肖日军, 胡兰, 谷铁波, 周晓峰. 卡维地洛对糖尿病心肌病病人代谢、炎症反应及心功能的影响[J]. 蚌埠医科大学学报, 2021, 46(1): 36-38, 43. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.010
    引用本文: 肖日军, 胡兰, 谷铁波, 周晓峰. 卡维地洛对糖尿病心肌病病人代谢、炎症反应及心功能的影响[J]. 蚌埠医科大学学报, 2021, 46(1): 36-38, 43. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.010
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    XIAO Ri-jun, HU Lan, GU Tie-bo, ZHOU Xiao-feng. Impact of carvedilol on the metabolism, inflammatory response and cardiac function of patients with diabetic cardiomyopathy[J]. Journal of Bengbu Medical University, 2021, 46(1): 36-38, 43. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.010
    Citation: XIAO Ri-jun, HU Lan, GU Tie-bo, ZHOU Xiao-feng. Impact of carvedilol on the metabolism, inflammatory response and cardiac function of patients with diabetic cardiomyopathy[J]. Journal of Bengbu Medical University, 2021, 46(1): 36-38, 43. DOI: 10.13898/j.cnki.issn.1000-2200.2021.01.010
    shu

    卡维地洛对糖尿病心肌病病人代谢、炎症反应及心功能的影响

    Impact of carvedilol on the metabolism, inflammatory response and cardiac function of patients with diabetic cardiomyopathy

      摘要
    • 摘要:
      目的探讨卡维地洛对糖尿病心肌病（DCM）病人代谢、炎症反应及心功能的影响。
      方法按照随机数字法将180例DCM病人分为对照组88例和观察组92例。对照组病人给予常规治疗，观察组病人在常规治疗的基础上加用卡维地洛（3.125~6.25 mg/d）。治疗12周后，比较2组生化指标总胆固醇（TC）、三酰甘油（TG）、空腹血糖（FBG）、炎症指标超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、心功能指标左室舒张末期内径（LVEDd）、左室收缩末期前后径（LVEDs）、左室射血分数（LVEF）、氨基末端脑钠肽前体（NT-pro-BNP）、6min步行距离以及不良反应发生情况。
      结果治疗后，2组病人的hs-CRP、TNF-α水平均明显下降（P < 0.01），且观察组的hs-CRP、TNF-α水平明显低于对照组（P < 0.01）。治疗后，2组LVEDd、LVEDs及NT-pro BNP水平均明显下降（P < 0.01），LVEF与6min步行距离均明显提高（P < 0.01）；且观察组的LVEDd、LVEDs及NT-pro BNP水平明显低于对照组（P < 0.01），LVEF与6min步行距离明显高于对照组（P < 0.01）。2组均未发生严重不良反应导致病例退出研究。对照组发生干咳2例、头痛头晕3例，观察组发生头痛头晕5例、恶心1例，2组不良反应发生情况差异无统计学意义（P>0.05）。
      结论卡维地洛能够显著改善对DCM病人的炎症状态及心功能，对血脂及血糖无明显影响。

       

      Abstract:
      ObjectiveTo discuss the impacts of carvedilol on metabolism, inflammatory response and cardiac function of patients with diabetic cardiomyopathy(DCM).
      MethodsOne hundred and eighty DCM patients were divided into the control group(n=88)and observation group(n=92)according to random number method in our hospital.The control group were treated with conventional method, and the observation group were additionally treated with carvedilol(3.125~6.25 mg/d)based on conventional method.After 12 weeks of treatment, the biochemical indexesincluding total cholesterol(TC), triglyceride(TG)and fasting blood-glucose(FBG), inflammation markersincluding high-sensitivity C-reactive protein(hs-CRP)and tumour necrosis factor-α(TNF-α), heart function parametersincluding left ventricular end diastolic diamete(LVEDd), left ventricular end-systolic diameter(LVEDs), left ventricular ejection fraction(LVEF), N-terminal pro-brain natriuretic peptid(NT-pro-BNP)and 6mmin walking distance and adverse reaction were compared between two groups.
      ResultsAfter treatment, the levels of hs-CRP and TNF-αin two groups significantly decreased(P < 0.01), and the levels of hs-CRP and TNF-α in observation group were significantly lower than those in control group(P < 0.01).After treatment, the levels of LVEDd, LVEDs and NT-pro BNP significantly decreased(P < 0.01), and the LVEF level and 6min walking distance significantly increased in two groups(P < 0.01).After treatment, the levels of LVEDd, LVEDs and NT-pro BNP in observation group were significantly lower than those in control group(P < 0.01), and the LVEF level and 6min walking distance in observation group were significantly higher than those in control group(P < 0.01).No severe adverse reaction occurred in two groups.The dry cough in 2 cases and headache in 3 cases in control group, and dizziness and headache in 5 cases and dizziness and nausea in 1 case in observation group were found, and the difference of the incidence of adverse reactions between two groups was not statistically significant(P>0.05).
      ConclusionsThe carvedilol can obviously improve the inflammatory state and cardiac function of DCM patients, and there is not significant effect on blood lipid and blood glucose.

       

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