老年慢性阻塞性肺疾病伴鼾症临床表型病人血清Caspase-3及Caspase-9水平相关性

戈艳蕾; 刘聪辉; 付爱双; 崔紫阳; 张婉; 解宝泉; 王袁; 王红阳; 张嘉宾

doi:10.13898/j.cnki.issn.1000-2200.2021.02.010

老年慢性阻塞性肺疾病伴鼾症临床表型病人血清Caspase-3及Caspase-9水平相关性

Relationship between serum levels of Caspase-3 and Caspase-9 and clinical phenotypes in COPD elderly patients complicated with snoring syndrome

摘要

摘要:
目的探讨老年慢性阻塞性肺疾病（COPD）伴鼾症临床表型病人血清Caspase-3及Caspase-9水平相关性。
方法选取老年COPD病人312例，根据病人是否存在鼾症，分为鼾症组及单纯组, 比较2组病人血清Caspase-3及Caspase-9水平变化，分析老年COPD伴鼾症临床表型病人血清Caspase-3及Caspase-9水平及其与睡眠监测指标相关性。
结果鼾症组血清Caspase-3及Caspase-9水平明显高于单纯组（P < 0.01）。鼾症组睡眠呼吸暂停低通气指数、氧减指数与血清Caspase-3及Caspase-9水平呈明显正相关关系（P < 0.01），夜间最低血氧饱和度、夜间平均血氧饱和度与血清Caspase-3及Caspase-9水平呈明显负相关关系（P < 0.01）。
结论在老年COPD伴鼾症临床表型病人，血清Caspase-3及Caspase-9水平增高与病人睡眠障碍低通气程度相关，睡眠障碍低通气程度越严重，血清Caspase-3及Caspase-9水平越高。

Abstract:
ObjectiveTo investigate the correlations of the serum levels of Caspase-3 and Caspase-9 with clinical phenotypes in chronic obstructive pulmonary disease(COPD)elderly patients complicated with snoring syndrome.
MethodsThree hundred and twelve elderly patients with COPD were divided into the snoring group and simple group according to the presence or absence of snoring syndrome.The serum levels of Caspase-3 and Caspase-9 were compared between two groups, and the relationships between serum levels of Caspase-3, Caspase-9 and sleep index in COPD elderly patients complicated with snoring syndrome were analyzed.
ResultsThe serum levels of Caspase-3 and Caspase-9 in snoring group were significantly higher than those in simple group(P < 0.01).The AHI and ODI in snoring group were significantly positively correlated with the serum levels of Caspase-3 and Caspase-9, and the LSaO₂ and MSaO₂ were negatively correlated with the serum levels of Caspase-3 and Caspase-9(P < 0.01).
ConclusionsThe high serum levels of Caspase-3 and Caspase-9 are correlated with the low degree of APNEA in elderly COPD patients complicated with snoring syndrome.The higher the serum levels of Caspase-3 and Caspase-9 are, the more severe of sleep disturbance is.

HTML全文

参考文献(13)

施引文献

资源附件(0)