非吸烟妇女牙周炎和妊娠期糖尿病关系研究

刘芬; 周志斐; 米阳; 郭娜; 李志斌

doi:10.13898/j.cnki.issn.1000-2200.2021.02.011

非吸烟妇女牙周炎和妊娠期糖尿病关系研究

Study on the relationship between periodontitis and gestational diabetes mellitus in nonsmoking women

摘要

摘要:
目的对非吸烟妇女牙周炎和妊娠期糖尿病（GDM）的关系进行调查，为妊娠期妇女GDM防治提供参考。
方法对纳入GDM妇女（GDM组）和正常对照妊娠期妇女（对照组）各250例进行全口牙周检查。牙周炎定义为口内≥1个位点存在≥5 mm探诊深度（PD）且同一位点牙周临床附着丧失（CAL）≥2 mm。采集纳入样本外周血检测C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和白介素-6（IL-6）表达水平。利用条件logistic回归检验对结果进行分析。
结果GDM组糖尿病家族史、孕前体质量指数高于对照组（P < 0.01）。GDM组PD、CAL、探诊出血位点百分数和患牙周炎率均高于对照组（P < 0.05~P < 0.01）。患有牙周炎和糖尿病家族史均为GDM的危险因素（P < 0.01）。GDM组CRP表达水平高于对照组（P < 0.01）。
结论牙周炎与GDM具有相关性。临床医生需对妊娠期妇女牙周状况给予关注。

Abstract:
ObjectiveTo investigate the relationship between periodontitis and gestational diabetes mellitus(GDM) in nonsmoking women for providing theoretic basis in treating and preventing this disease.
MethodsThe total periodontal examination was performed on 250 GDM women(GDM group) and 250 normal pregnant women(control group).The periodontitis was defined as the presence of ≥5 mm probing depth(PD) at ≥1 site in the mouth and loss of clinical periodontal attachment(CAL) at the same site ≥2 mm.The expression levels of C reactive protein(CRP), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in two groups were measured in peripheral blood, and the conditional logistic regression test was used to analyze the results.
ResultsThe family history of diabetes and prepregnancy body mass index in GDM group were higher than those in control group(P < 0.01).The percentage of PD, CAL, exploratory bleeding site and rate of periodontitis in GDM group were higher than those in control group(P < 0.05 to P < 0.01).The periodontitis and family history of diabetes were the risk factors of GDM(P < 0.01).The CRP expression level in GDM group was higher than that in control group(P < 0.01).
ConclusionsThe periodontitis is associated with GDM.The clinicians should pay attention to the periodontal status of pregnant women.

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