实时剪切波弹性成像技术监测肝豆状核变性病人合并脾脏肿大对肝脏硬度的影响

王佳佳; 王艺星; 刘晨旭; 肖蕾; 张靖; 李保启; 王金萍

doi:10.13898/j.cnki.issn.1000-2200.2021.02.026

实时剪切波弹性成像技术监测肝豆状核变性病人合并脾脏肿大对肝脏硬度的影响

Effect of the hepatolenticular degeneratioin complicated with splenomegaly on the liver hardness monitored by real-time shear wave elastography

摘要

摘要:
目的利用实时剪切波弹性成像技术测量肝豆状核变性病人肝脏剪切波速度（shear wave velocity, SWV），定量评估合并脾脏肿大的肝豆状核变性病人肝脏质地的变化情况。
方法根据肝豆状核变性病人脾脏是否增大，将病人分为2组，应用配备声脉冲辐射力成像软件的西门子ACUSON-OXANA3型彩色多普勒超声诊断仪，测量研究对象肝右叶SWV，并利用SPSS25.0软件对2组病人的肝右叶SWV值进行独立样本t检验。
结果脾脏不大的病人14例，并发脾脏增大的病人共计24例，2组间肝右叶SWV值差异有统计学意义（P < 0.05）。
结论分组定量测量肝脏SWV速度，有助于临床在肝豆状核变性病人治疗过程中及时调整治疗方案。

Abstract:
ObjectiveTo evaluate the effects of hepatolenticular degeneration(HLD)complicated with splenomegaly on liver hardness through real-time shear wave elastography measuring the liver shear wave velocity(SWV).
MethodsThe patients with HLD were divided into two groups according to the splenomegaly.The right liver lobe SWV of patients were measured using Siemens ACUSON-OXANA3 color doppler ultrasonic diagnostic instrument with acoustic radiation force impulse imaging(ARFI), and the right liver lobe SWV values in two groups were analyzed by independent sample t test using SPSS 25.0 software.
ResultsFourteen patients without splenomegaly and 24 patients with splenomegaly were identified in two groups, respectively.The difference of the SWV value of the right lobe of liver between two groups was statistically significant(P < 0.05).
ConclusionsThe quantitative measurement of liver SWV velocity is helpful to timely adjust the treatment plan in the clinical treatment of patients with hepatolenticular degeneration.

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