ObjectiveTo investigate the changes of amplitude-integrated electroencephalography(aEEG) in late preterm infants with periventricular-intraventricular hemorrhage(PIVH), and its clinical value in early diagnosis of PIVH.

MethodsA total of 82 late preterm infants with gestational age ranging from 34-36⁺⁶ weeks were selected.The aEEG and craniocerebral ultrasound examination in the cases were performed within 72 hours and 10 d days after birth, respectively.According to the different gestational ages, the patients were divided into the 34-week group(34-34⁺⁶ weeks), 35-week group(35-35⁺⁶ weeks) and 36-week group(36-36⁺⁶ weeks).According to the results of craniocerebral ultrasonography, each gestational age group was subdivided into the PIVH group and non-PIVH group.

ResultsAmong three gestational ages groups, the total score, sleep wake cycle score and bandwidth scores of 35-week and 36-week patients of aEEG in PIVH group were lower than those in non-PIVH group(P < 0.01).When the Youden index was the largest, the optimal cutoff value of total score, sensitivity and specificity in 34-week, 35-week and 36-week groups were (8.5, 73.31% and 81.80%), (9.5, 71.43% and 92.32%) and (10.5, 84.62% and 87.51%), respectively.

ConclusionsThe total score, sleep wake cycle and bandwidth scores in 35-and 36-week patients of aEEG in PIVH group are lower than those in non-PIVH group.The aEEG has high sensitivity and specificity for PIVH diagnosis when the optimal cutoff value is selected for each gestational age.