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    2型糖尿病病人尿ACR与血清胱抑素C及β2微球蛋白的相关性研究

    Correlation between urine ACR and serum cystatin C, β2-microglobulin in type 2 diabetes mellitus patients

      摘要
    • 摘要:
      目的探讨2型糖尿病（T2DM）病人尿白蛋白肌酐比值（ACR）与血清胱抑素C（Cys-C）及血清β2微球蛋白（β2-MG）的相关性。
      方法将530例2型糖尿病病人依据ACR进行分组：正常白蛋白尿组（NA组，ACR < 30 mg/g）361例，微量白蛋白尿组（MA组30 mg/g≤ACR < 300 mg/g）118例和大量白蛋白尿组（LA组ACR≥300 mg/g）51例。比较各组体质量指数（BMI）、尿素氮（BUN）、血肌酐（Scr）、Cys-C、β2-MG、空腹血糖（FPG）、糖化血红蛋白（HbA1c）的差异，并对Cys-C、β2-MG分别与尿ACR行相关性分析。
      结果NA、MA、LA 3组中，性别、BMI、FPG差异无统计学意义（P>0.05），HbA1C水平MA组高于NA组（P < 0.01）；BUN和Scr水平LA组高于NA组和MA组（P < 0.01）；Cys-C和β2-MG水平，NA组 < MA组 < LA组（P < 0.05~P < 0.01）。经Pearson相关分析，血清Cys-C、β2-MG与均尿ACR呈正相关（r=0.402和r=0.624，P < 0.01）。
      结论随着肾功能损害程度加重，T2DM病人血清Cys-C、β2-MG水平也随之逐渐上升，且与尿ACR具有很好的相关性，因此对糖尿病肾病的早期诊断、治疗和病情监测具有重要的意义。

       

      Abstract:
      ObjectiveTo investigate the correlation between urine albumin-creatinine ratio(ACR), and serum cystatin C(Cys-C) and serum β2-microglobulin(β2-MG) in patients with type 2 diabetes mellitus.
      MethodsA total of 530 patients with type 2 diabetes mellitus were divided into the normal albuminuria group(NA group, 361 cases with ACR < 30 mg/g), microalbuminuria group(MA group, 118 cases with 30 mg/g ≤ ACR < 300 mg/g) and large albuminuria group(LA group, 51 cases with ACR ≥ 300 mg/g) according to the ACR level.The body mass index(BMI), blood urea nitrogen(BUN), serum creatinine(Scr), Cys-C, β2-MG, fasting plasma glucose(FPG) and glycosylated hemoglobin(HbA1c) were compared among three groups, and the correlation between Cys-C, β2-MG and urine ACR was analyzed.
      ResultsThe differences of the gender, BMI and FPG among the NA, MA and LA groups were not statistically significant(P>0.05).The level of HbA1c in MA group was higher than that in NA group(P < 0.01).The levels of BUN and Scr in LA group were higher than those in NA group and MA group(P < 0.01).The levels of Cys-c and β2-MG in NA group, MA group and LA group gradually increased(P < 0.05 to P < 0.01).The results of Pearson correlation analysis showed that the serum levels of Cys-C and β2-MG were positively correlated with urine ACR(r=0.402 and r=0.624, P < 0.01).
      ConclusionsWith the aggravation of renal function damage, the serum levels Cys-C and β2-MG in type 2 diabetes mellitus patients gradually increase, which has good correlation with urine ACR, so it is of great significance in the early diagnosis, treatment and condition monitoring of diabetic ridney disease.

       

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