CalliSpheres载药微球栓塞治疗原发性巨块型肝癌病人的疗效及对肿瘤标志物、肝功能的影响

陈品; 田世江; 张宏坤; 袁德鹏

doi:10.13898/j.cnki.issn.1000-2200.2021.04.022

CalliSpheres载药微球栓塞治疗原发性巨块型肝癌病人的疗效及对肿瘤标志物、肝功能的影响

Efficacy of CalliSpheres drug-loaded microsphere embolization in the treatment of primary massive liver cancer, and its effects on tumor markers and liver function

摘要

摘要:
目的探究CalliSpheres载药微球栓塞治疗原发性巨块型肝癌病人的疗效及对肿瘤标志物、肝功能的影响。
方法选取原发性巨块型肝癌病人80例作为研究对象，按照随机数字表法分为2组，各40例。对照组给予碘油经导管动脉化疗栓塞，观察组给予CalliSpheres载药微球经导管动脉化疗栓塞。比较2组术后1个月、3个月临床效果、术后并发症发生情况及血清肿瘤标志物糖类抗原199（CA199）、甲胎蛋白（AFP）、E-钙黏蛋白（EC）、肝功能指标天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）、总胆红素（TBIL）、白蛋白（Alb）水平，并统计对比2组1年生存率。
结果观察组术后3个月疾病缓解率、疾病控制率（57.50%、82.50%）均高于对照组（30.00%、60.00%）（P < 0.05）；观察组术后1个月、3个月血清CA199、AFP、EC水平均低于对照组（P < 0.01）；观察组术后3个月血清AST、ALT、TBIL水平均低于对照组（P < 0.01），Alb水平高于对照组（P < 0.01）；观察组发热发生率、CINV分级均低于对照组（P < 0.05和P < 0.01）；观察组术后1年生存率（73.68%）高于对照组（51.35%）（P < 0.05）。
结论采用CalliSpheres载药微球栓塞治疗原发性巨块型肝癌病人，能进一步改善治疗效果，且对病人肝功能影响更小，可有效降低不良反应发生率，提高病人1年生存率。

Abstract:
ObjectiveTo investigate the effects of CalliSpheres drug-loaded microsphere embolization in the treatment of primary massive liver cancer, and its effects on tumor markers and liver function.
MethodsEighty patients with primary massive liver cancer were divided into the control group and observation group according to the random number table method(40 cases in each group).The control group was treated with iodized oil transcatheter arterial chemoembolization, and the observation group was treated with CalliSpheres drug-loaded microsphere transcatheter arterial chemoembolization.The clinical effects, postoperative complications, and serum tumor markersincluding carbohydrate antigen 199(CA199), α-fetoprotein(AFP) and E-cadherin(EC), liver function indexincluding aspartate aminotransferase(AST), alanine aminotransferase(ALT), total bilirubin(TBIL) and albumin(Alb) levels between two groups after 1 and 3 months of operation were compared.The 1-year survival rate was compared between two groups.
ResultsThe disease remission rate and disease control rate(57.50% and 82.50%) in observation group were higher than those in control group after 3 months of operation(30.00% and 60.00%) (P < 0.05).The serum levels of CA199, AFP and EC in observation group after 1 and 3 months of operation were lower than those in control group(P < 0.01).After 3 months of operation, the serum levels of AST, ALT, TBIL in observation group were lower than those in control group(P < 0.01), and the level of Alb in observation group was higher than that in control group(P < 0.01).The incidence rate of fever and CINV grade in observation group were lower than those in control group(P < 0.05 and P < 0.01).The 1-year survival rate in observation group(73.68%) was higher than that in control group(51.35%)(P < 0.05).
ConclusionsThe CalliSpheres drug-loaded microsphere embolization in the treatment of primary massive liver cancer can further improve the therapeutic effects, has less impact on the liver function, and can effectively reduce the incidence rate of adverse reactions and improve the 1-year survival rate of patients.

HTML全文

参考文献(21)

施引文献

资源附件(0)