p53和TAZ在三阴性乳腺癌中的表达和意义

祝景伟; 孟超; 佟经伟; 许培权

doi:10.13898/j.cnki.issn.1000-2200.2021.04.023

p53和TAZ在三阴性乳腺癌中的表达和意义

Expression and significance of p53 and TAZ in triple negative breast cancer

摘要

摘要:
目的研究三阴性乳腺癌（TNBC）组织中p53与TAZ的表达和意义，并探讨其与TNBC病人临床病理特征的关系。
方法收集病理确诊的浸润性乳腺癌60例TNBC组30例，非三阴性乳腺癌（non-TNBC）组30例，应用免疫组织化学方法检测60例乳腺癌组织中p53和TAZ的表达情况，并分析它们与TNBC病人的年龄、肿瘤大小、淋巴结转移、TNM分期及组织学分级等的关系。
结果TAZ在TNBC组织中的表达高于non-TNBC组（P < 0.01）；年龄≤45岁、肿瘤>2 cm的p53的阳性表达率较高（P < 0.05），肿瘤>2 cm、组织学分级Ⅰ~Ⅱ TAZ的阳性表达率较高（P < 0.01和P < 0.05）；在TNBC中，p53与TAZ的表达呈正相关（r_s=0.381，P < 0.05）。
结论TAZ可能与TNBC的发生发展有关。

Abstract:
ObjectiveTo study the expression and significance of p53 and transcriptional co-activator with PDZ binding motif(TAZ) in triple negative breast cancer(TNBC), and explore their relationship with the clinicopathological characteristics in TNBC patients.
MethodsSixty patients with invasive breast cancer diagnosed by pathology were divided into the TNBC group(30 cases) and non-TNBC group(30 cases).The expression levels of p53 and TAZ in cancer tissue were detected using immunohistochemistry.The relationship between the expression levels of p53 and TAZ, and age, tumor size, lymph node metastasis, TNM stage and histological grade of TNBC patients were analyzed.
ResultsThe expression level of TAZ in TNBC group was higher than that in non-TNBC group(P < 0.01).The positive expression rates of p53 in patient age ≤ 45 years old and tumor >2 cm were higher, while the positive expression rates of TAZ in tumor >2 cm and histological grade Ⅰ-Ⅱ were higher(P < 0.01 and P < 0.05).In TNBC group, the expression level of p53 was positively correlated with TAZ expression(r_s=0.381, P < 0.05).
ConclusionsTAZ may be involved in the development of TNBC.

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