平均血小板体积/淋巴细胞比值对急性脑梗死严重程度的预测价值

方明昊; 钱伟东

doi:10.13898/j.cnki.issn.1000-2200.2021.05.008

平均血小板体积/淋巴细胞比值对急性脑梗死严重程度的预测价值

The predictive value of mean platelet volume-to-lymphocyte ratio in the severity of acute cerebral infarction

摘要

摘要:
目的探讨平均血小板体积/淋巴细胞比值（mean platelet volume-to-lymphocyte ratio，MPVLR）对急性脑梗死严重程度的预测价值。
方法回顾性分析109例急性脑梗死病人的临床资料，根据NIHSS评分将其分为轻度组（n=64）和中重度组（n=45）。根据2组血常规相关指标，计算MPVLR。采用二分类logistic回归分析急性脑梗死病情的影响因素，利用ROC曲线评价入院时MPVLR水平对急性脑梗死病变严重程度的预测价值。
结果轻度组MPVLR、单核细胞计数均低于中重度组，差异均有统计学意义（P < 0.05）。二元logistic回归分析显示，入院时MPVLR水平的增加，为急性脑梗死病情严重程度的独立危险因素。ROC曲线显示，MPVLR预测急性脑梗死严重程度的ROC曲线下面积为0.745（95%CI：0.653~0.824），最佳截断值为5.36，敏感度为80.0%，特异度为62.5%。
结论MPVLR对急性脑梗死严重程度具有一定预测价值。

Abstract:
ObjectiveTo explore the predictive value of the mean platelet volume-to-lymphocyte ratio(MPVLR) in the severity of acute cerebral infarction.
MethodsA total of 109 patients with acute cerebral infarction were retrospectively analyzed, and divided into the mild group(n=64) and moderate-severe group(n=45) according to the NIHSS score.The MPVLR was calculated according to the blood routine indexes of two groups.The influencing factors of acute cerebral infarction were analyzed using dichotomous logistic regression, and the predictive value of MPVLR level on admission in the severity of acute cerebral infarction was evaluated using ROC curve.
ResultsThe MPVLR and monocyte counts in mild group were lower than those in moderate group(P < 0.05).The results of binary logistic regression analysis showed that the increasing of MPVLR level on admission was an independent predictor of acute cerebral infarction.The results of ROC curve showed that the area under the curve of MPVLR predicting the severity of acute cerebral infarction was 0.745(95%CI: 0.653~0.824), and the best cutoff value, sensitivity and specificity were 5.36, 80.0% and 62.5%, respectively.
ConclusionsThe MPVLR has certain predictive value in judging the severity of acute cerebral infarction.

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