ObjectiveTo investigate the influencing factors of acute kidney injury(AKI) in patients with septic shock.

MethodsA total of 144 patients with septic shock were divided into the AKI group and non-AKI group according to the incidence of AKI.The general data and clinical indicators between two groups were compared, and analyzed using the univariate analysis method.The items with significant difference were analyzed using the logistic regression analysis method to explore the influencing factors of AKI.

ResultsThe differences of the combined diabetes, mean arterial pressure, glomerular filtration rate, levels of serum lactate, urea nitrogen and D-dimer, mechanical ventilation, blood purification therapy, maximum daily dose of furosemide were statistically significant(P < 0.05 to P < 0.01).The differences of the age, gender and body mass index between two groups were not statistically significant(P>0.05).The results of logistic regression analysis showed that the combined diabetes, mean arterial pressure, serum lactate level, mechanical ventilation and maximum daily dose of furosemide were the independent factors influencing AKI in patients with septic shock(P < 0.05 to P < 0.01).

ConclusionsThe incidence rate of AKI is higher in patients with septic shock.The combined diabetes, mean arterial pressure, serum lactate level, mechanical ventilation, maximum daily dose of furosemide are the independent factors influencing AKI in patients with septic shock, and the clinical intervention measures should be taken early for high-risk patients.