新生儿急性胆红素脑病应用脑干听觉诱发电位早期诊断的研究

Value of BAEP in the early diagnosis of acute bilirubin encephalopathy in the newborn

摘要:
目的探讨脑干听觉诱发电位（BAEP）、头颅磁共振成像（MRI）与新生儿急性胆红素脑病（ABE）临床诊断的相关性及敏感性。
方法回顾性选取新生儿科收治、胎龄>37周的高胆红素血症新生儿为研究对象，分为ABE组（37例）和非ABE组（92例），比较2组患儿血清总胆红素水平、BAEP以及MRI变化。
结果ABE组患儿血清总胆红素水平、BAEP异常率和MRI异常率均高于非ABE组（P<0.01）。
结论血清总胆红素水平检测、BAEP及头颅MRI可作为新生儿ABE早期诊断的指标，BAEP对ABE的诊断有较高的敏感性。

Abstract:
ObjectiveTo investigate the correlation and sensitivity of brain stem auditory evoked potential(BAEP) and cranial magnetic resonance imaging(MRI) in the diagnosis of acute bilimbin encephalopathy(ABE) in the newborn.
MethodsThe clinical data of newborn with hyperbilirubinemia and aged >37 weeks were retrospectively analyzed, and divided into the ABE group(37 cases) and non-ABE group(92 cases).The total serum bilirubin level, changes of BAEP and MRI were compared between two groups.
ResultsThe total serum bilirubin level, abnormal rates of BAEP and MRI in ABE group were higher than those in non-ABE group(P<0.01).
ConclusionsThe total serum bilirubin level, BAEP and cranial MRI can be used as the indicators for the early diagnosis of neonatal ABE, and the BAEP is highly sensitive to ABE diagnosis.