血清胱抑素C水平与脑白质病变严重程度的相关性研究

史肖锦; 梁彩霞; 赵宾; 汪国胜; 钟平

doi:10.13898/j.cnki.issn.1000-2200.2021.08.006

血清胱抑素C水平与脑白质病变严重程度的相关性研究

Study on the correlation between serum level of cystatin C and severity of white matter lesions

摘要

摘要:
目的探讨脑白质病变（white matter lesions，WMLs）严重程度与血清胱抑素C（cystatin C，CysC）水平的相关性。
方法选择123例经MRI检查确诊的WMLs病人，按照Fazekas量表评估分为轻、中、重度组，收集各组病人血清CysC水平等临床相关资料；采用logistic回归分析WMLs的危险因素，分析各组间CysC水平与WMLs严重程度的相关性。
结果重度组病人CysC水平较轻、中度组明显升高（P < 0.01）；多因素logistic回归分析结果显示，年龄大、高血压、血清CysC水平高均为WMLs的独立危险因素（P < 0.05~P < 0.01）。Spearman等级相关分析表明，血清CysC水平升高与WMLs的严重程度呈正相关（r=0.410，P < 0.05）。
结论血清CysC水平与WMLs的严重程度密切相关。

Abstract:
ObjectiveTo explore the correlation between serum cystatin C(CysC) level and severity of white matter lesions(WMLs).
MethodsOne hundred and twenty-three WMLs patients confirmed by MRI were divided into the mild, moderate and severe groups according to the Fazekas scale, and the serum levels of CysC and other clinical indicators in all cases were collected.The risk factors of WMLs were analyzed using logistic regression analysis, and the correlation between CysC level and WMLs severity were analyzed among three groups.
ResultsThe level of CysC in severe group was significantly higher than that in mild and moderate groups(P < 0.01).The results of multivariate logistic regression analysis showed that the older age, hypertension and high serum CysC level were all independent risk factors of WMLs(P < 0.05 to P < 0.01).The results of Spearman correlation analysis revealed that the CysC level was positively correlated with the severity of WMLs(r=0.410, P < 0.05).
ConclusionsThe serum level of CysC is closely related to the severity of WMLs.

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