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    风险计算器与中性粒细胞/淋巴细胞比值在新生儿早发型败血症中的预测价值

    Value of risk calculator and neutrophil/lymphocyte ratio in the prediction of neonatal early-onset sepsis

      摘要
    • 摘要:
      目的分析败血症风险计算器与中性粒细胞/淋巴细胞比值（neutrophil/lymphocyte ratio，NLR）在新生儿早发型败血症（early-onset sepsis，EOS）的预测价值。
      方法回顾性分析43例诊断为EOS患儿及43例同期住院非感染性疾病患儿的临床及实验室资料，使用败血症风险计算器评估其EOS的发病风险，采用受试者工作特征（ROC）曲线评估败血症风险计算器与NLR的诊断效能。
      结果败血症组NLR为3.89±3.11，对照组为1.82±0.73，差异有统计学意义（P < 0.01）。败血症组风险计算器计算每千例患儿发病风险系数为4.03±10.31，对照组为0.02±0.06，差异有统计学意义（P < 0.05）。风险计算器、NLR、二者联合ROC曲线下面积分别为0.857、0.710、0.910，诊断灵敏度分别为74.4%、62.8%、83.7%，特异度分别为97.7%、90.7%、97.7%，风险计算器与NLR两者联合高于单独检测NLR的诊断效能（P < 0.01）。
      结论败血症风险计算器与NLR对EOS均有较高预测价值，两者联合有助于EOS的早期诊断与治疗。

       

      Abstract:
      ObjectiveTo investigate the value of risk calculator and neutrophil/lymphocyte ratio(NLR) in the prediction of the neonatal early-onset sepsis(EOS).
      MethodsThe clinical and laboratory data of 43 patients diagnosed by EOS(sepis group) and 43 hospitalized patients with non-infectious diseases(control group) were retrospectivly analyzed.The risk of EOS was assessed using the sepsis risk calculator, and the diagnostic efficacy of the sepsis risk calculator and NLR were assessed using the receiver operating characteristic(ROC) curve.
      ResultsThe NLR value in the sepsis group and control group was(3.89±3.11) and (1.82±0.73), respectively, and the difference of which between two groups was statistical significant(P < 0.01).The incidence risk coefficient per thousand children in the sepsis group and control group was(4.03±10.31) and (0.02±0.06), respectively, and the difference of which between two groups was statistical significan(P < 0.05).The area under the curve, diagnostic sensitivity and specificity of the risk calculator, NLR and their combination were (0.857, 0.710 and 0.910, respectively), (74.4%, 62.8% and 83.7%, respectively) and (97.7%, 90.7% and 97.7%, respectively), respectively.The diagnostic efficiency of the risk calculator combined with NLR was higher than that of NLR alone(P < 0.01).
      ConclusionsBoth the sepsis risk calculator and NLR have high predictive value for EOS, and the combination of the two is helpful for the early diagnosis and treatment of EOS.

       

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