局部晚期下咽癌根治性放射治疗的疗效及预后因素分析

汪庚明; 周燕; 孙谦; 周育夫; 丁建明; 周士祥; 郭术楠; 陈蔓

doi:10.13898/j.cnki.issn.1000-2200.2021.09.002

局部晚期下咽癌根治性放射治疗的疗效及预后因素分析

Study on the clinical efficacy of radical radiotherapy in locally advanced hypopharyngeal carcinoma and prognostic factors

摘要

摘要:
目的分析根治性放射治疗对局部晚期下咽癌的临床疗效，并对其影响预后的相关因素进行评价。
方法回顾性分析2016年10月至2018年12月25例局部晚期下咽癌病人的临床资料，通过Kaplan-Meier法计算总生存时间，应用Cox比例风险回归模型进行单因素和多因素分析。
结果近期有效率为100%。中位生存时间为17个月，2年生存率为32.0%。通过单因素分析，结果显示N分期、临床分期、近期疗效、是否同步化疗与生存预后有关（P < 0.01）。多因素分析结果表明，临床分期和是否同步化疗是下咽癌病人预后的独立影响因素（P < 0.01和P < 0.05）。
结论根治性放射治疗局部晚期下咽癌近期疗效确切，临床分期和是否同步化疗是影响其预后的独立危险因素。

Abstract:
ObjectiveTo analyze the clinical effects of radical radiotherapy in the treatment of locally advanced hypopharyngeal cancer, and evaluate the prognostic factors.
MethodsThe clinical data of 25 patients with locally advanced hypopharyngeal carcinoma from October 2016 to December 2018 were retrospectively analyzed.The overall survival of patients was calculated using Kaplan-Meier method.The Cox model was used for univariate analysis and multivariate analysis.
ResultsThe recent effective rate was 100%.The median surviual time was 25 months.The 2-year surviual rate was 32.0%.The results of univariate analysis indicated that the N stage, clinical stage, recent effective rate and concurrent chemotherapy were the prognostic factors(P < 0.01).The results of multivariate analysis showed that the clinical stage and concurrent chemotherapy were the independent prognostic factors(P < 0.01 and P < 0.05).
ConclusionsThe short-term effects of radical radiotherapy for locally advanced hypopharyngeal carcinoma is definite.The clinical stage and concurrent chemotherapy are the independent prognostic factors.

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