基于淋巴结比率的45岁以上病人胃癌分期的新方法

王后红; 谢宗玉; 朱博; 何新阳

doi:10.13898/j.cnki.issn.1000-2200.2021.09.006

基于淋巴结比率的45岁以上病人胃癌分期的新方法

A new method for staging gastric cancer in patients over 45 years old based on the lymph node ratio

摘要

摘要:
目的评估淋巴结比率（LNR）作为45岁以上胃癌病人分期评估的实用性。
方法接受根治性胃切除术的45岁以上病人236例，收集包括回收的淋巴结（LN）和转移性淋巴结（LNs）的临床病理数据，并计算LNR值（LNR=LNs/LN）。根据危险比（HR）增加的截止点，将间隔为0.1的LNR组分为4个阶段。进行生存分析以评估LNR的预后价值。
结果4个LNR级包括LNR0（n=89），LNR1（n=47），LNR2（n=90）和LNR3（n=10）。在多变量分析中，N分期和LNR分期均显示出显著的预后价值，可预测生存结果。LNR分期在连续阶段之间的HR的增量变化大于N分期（HR：N分期为1.583、2.789和4.581；LNR分期为1.469、3.837和8.572）。
结论LNR分期作为一种新颖且简单的评估方法，在预测45岁以上胃癌病人的预后和复发方面具有一定的临床应用价值。

Abstract:
ObjectiveTo evaluate the utility of lymph node ratio(LNR) in the staging assessment of patients over 45 years old with gastric cancer.
MethodsThe patients aged 45 years or older treated with radical gastrectomy were investigated, the clinicopathological data of recovered lymph nodes(LN) and metastatic lymph nodes(LNs) were collected, and the LNR values were obtained(LNR=LNs/LN).The LNR group with 0.1 intervals was divided into four phases based on the cutoff point of increased hazard ratio(HR).The survival analysis was performed to assess the prognostic value of LNR.
ResultsThe four LNR levels included the LNR0(n=89), LNR1(n=47), LNR2(n=90) and LNR3(n=10).In the multivariate analysis, both N staging and LNR staging showed the significant prognostic value, and which could predict the survival outcome.The incremental changes in the HR among successive stages of LNR staging were greater than those of N staging(HR: the N staging was 1.583, 2.789 and 4.581, and the LNR staging was 1.469, 3.837 and 8.572).
ConclusionsThe LNR staging, a novel and simple marker, has certain clinical application value in predicting the prognosis and recurrence of gastric cancer in patients over 45 years old.

HTML全文

参考文献(15)

施引文献

资源附件(0)