ObjectiveTo compare the direct economic loss caused by nosocomial infection in patients with spontaneous intracerebral hemorrhage and the cost, benefit and effect after implementing the infection prevention and control program.

MethodsThe patients with first diagnosed spontaneous intracerebral hemorrhage among the patients discharged from January 1, 2019 to December 31, 2019 were set as the control group, and the patients with spontaneous intracerebral hemorrhage discharged from January 1, 2020 to December 31, 2020 after implementing the infection control program were set as the observation group.The changes in the risk of nosocomial infection in patients with intracerebral hemorrhage was compared before and after implementing the infection control program.At the same time, patients with spontaneous intracerebral hemorrhage with nosocomial infection in the past two years were selected as the infection group, and patients without nosocomial infection were selected as the control group (non-infection group) according to the 1:1 matching method.The differences of hospitalization time and various hospitalization costs between the two groups were compared.

ResultsIn 2019 and 2020, there were 215 and 189 patients with spontaneous intracerebral hemorrhage, respectively, and there were 25 and 11 patients with nosocomial infection, respectively.The incidence of nosocomial infection in 2020 was significantly lower than that in 2019(P < 0.01).Combined with the occurrence of nosocomial infection in patients with intracerebral hemorrhage for 2 years, a total of 27 pairs of case controls meeting the requirements were matched.The median hospitalization time of patients in the infection group and non-infection group was 26 days and 17 days, respectively, which was extended in the non-infection group(P < 0.01).The median hospitalization costs were 79 889.03 yuan and 18 662.37 yuan in the infection group and non-infection group, respectively, and the direct economic loss of the total hospitalization cost was 61 226.66 yuan(P < 0.05).The cost of medicine, examination, laboratory test, diagnosis, bed, surgery, treatment and nursing in the infection group were higher than those in the control group(P < 0.05).

ConclusionsNosocomial infection in patients with spontaneous intracerebral hemorrhage causes the prolongation of hospitalization time and significant increase of hospitalization costs.The implementation of infection control program can achieve good benefits and effects.