Objective To explore the effects of hyperbaric oxygen combined with r-globulin on the rehabilitation and levels of β-endorphin(β-EP), myelin basic protein(MBP) and myocardial enzyme spectrum in children with viral encephalitis(VE).

Methods One hundred and ten children with VE were divided into the observation group and control group using random number table method(55 cases in each group).The control group was treated with r-globulin, while the observation group was treated with hyperbaric oxygen combined with r-globulin.The clinical efficacy, clinical symptom, relief time, levels of β-EP, MBP and myocardial enzyme spectrum, and incidence rate of sequelae were observed in two groups.

Results The therapeutic efficiency in observation group(90.91%) was significantly higher than that in control group(72.73%) (P < 0.01).The remission time of fever, headache, nausea and vomiting and consciousness in observation group were significantly lower than those in control group(P < 0.01).After treatment, the serum levels of β-EP and MBP in two groups significantly decreased(P < 0.01), and which in observation group were significantly lower than those in control group(P < 0.01).After treatment, the serum levels of LDH、CK、CK-MB and AST in two groups significantly decreased(P < 0.01), and which in observation group were significantly lower than those in control group(P < 0.01).The incidence rate of sequelae in observation group(9.01%) was significantly lower than that in control group(23.64%) (P < 0.05).

Conclusions Hyperbaric oxygen combined with r-globulin can effectively treat the VE.The neurologic function can be improved, and the incidence rate of sequelae can be reduced by decreasing the levels of β-EP, MBP and myocardial enzyme in VE children.It is worthy of clinical promotion.