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    老年原发性高血压病人血尿酸水平与动态血压的关系

    Relationship of serum uric acid and ambulatory blood pressure in elderly patients with primary hypertension

      摘要
    • 摘要:
      目的 探讨老年原发性高血压病人体内血尿酸水平与动态血压的关系。
      方法 随机选取61例老年原发性高血压病人进行24 h动态血压检查，并采血检测血尿酸水平，根据血尿酸水平中位数将病人分为尿酸正常组（NUA组）和尿酸偏高组（HUA组），比较2组24 h收缩压和舒张压平均值（24hSBP和24hDBP）、白昼收缩压和舒张压平均值（dSBP和dDBP）、夜间收缩压和舒张压平均值（nSBP和nDBP），及血压变异性（BPV）参数包括24 h收缩压标准差（24hSBPSD）、24 h舒张压标准差（24hDBPSD）。并行相关分析血尿酸水平与各动态血压参数的相关性。按24hSBP再将病人分为血压控制良好组和血压控制不良组，比较2组血尿酸水平和动态血压各参数的区别。
      结果 HUA组24hSBP、dSBP和24hSBPSD均较NUA组增高（P < 0.05），并与血尿酸水平呈显著正相关关系（P < 0.05~P < 0.01）；血压控制良好组血尿酸水平低于血压控制不良组（P < 0.01）；血压控制良好组24hSBP、dSBP和nSBP水平均低于血压控制不良组（P < 0.01）。
      结论 老年原发性高血压病人血尿酸水平越高，收缩压也随之增高，收缩压BPV也越大，监测血尿酸水平对高血压的防治有重要临床意义。

       

      Abstract:
      Objective To explore the relationship of serum uric acid and ambulatory blood pressure in patients with primary hypertension.
      Methods The 24-hour ambulatory blood pressure in 61 elderly patients with primary hypertension was monitored, and the serum levels of uric acid were detected.According to the median level of serum uric acid, the patients were divided into the normal uric acid group(NUA group) and high uric acid group(HUA group).The 24 h average systolic and diastolic blood pressure(24hSBP and 24hDBP), daytime average systolic and diastolic blood pressure(dSBP and dDBP), nighttime average systolic and diastolic blood pressure(nSBP and nDBP) and blood pressure variability(BPV)including 24-hour systolic blood pressure standard deviation(24hSBPSD) and 24-hour diastolic blood pressure standard deviation(24hDBPSD) were compared between two groups.The correlation between serum uric acid level and blood pressure indexes was analyzed.According to 24hSBP, the patients were devided into the group with good blood pressure control and the group with poor blood pressure control, and the differences of serum uric acid level and ambulatory blood pressure parameters between the two groups were compared.
      Results The 24hSBP, dSBP and SBPSD in HUA group were higher than those in NUA group(P < 0.05), and significantly positively correlated with the serum uric acid level(P < 0.05 to P < 0.01).The uric acid level in the group with good blood pressure control was lower than that in the group with poor blood pressure control(P < 0.01).The levels of SBP, dSBP and nSBP in the group with good blood pressure control were lower than those in the group with poor blood pressure control(P < 0.01).
      Conclusions With the increasing of the level of serum uric acid in patients with primary hypertension, the systolic blood pressure and BPV increase.Monitoring the serum uric acid has important clinical significance in the prevention of hypertension.

       

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