银杏叶提取物联合高压氧治疗老年阿尔茨海默症的疗效

汪小荣; 周汝娟; 丁春琴

doi:10.13898/j.cnki.issn.1000-2200.2021.12.026

银杏叶提取物联合高压氧治疗老年阿尔茨海默症的疗效

Efficacy of Ginkgo Folium extract combined with hyperbaric oxygen in the treatment of Alzheimer's disease in the elderly

摘要

摘要:
目的探究银杏叶提取物联合高压氧治疗老年阿尔茨海默症的疗效。
方法选取老年阿尔茨海默症病人98例，按随机数字表法分为2组，各49例。对照组采用银杏叶提取物进行治疗，观察组在此基础上联合高压氧治疗。对比2组临床疗效、血清指标及不良反应发生率。
结果观察组治疗后简易精神状态量表评分、日常生活能力量表评分高于对照组，阿尔茨海默症认知量表评分低于对照组（P < 0.01）；观察组治疗后超氧化物岐化酶、谷胱甘肽过氧化物酶、细胞生长因子β1水平均高于对照组，丙二醛、白细胞介素1β水平均低于对照组（P < 0.01）；观察组乏力、恶心、头晕、失眠、皮疹发生率与对照组相比差异无统计学意义（P>0.05）。
结论银杏叶提取物联合高压氧治疗老年阿尔茨海默症可有效提高临床疗效，改善血清相关指标，且不良反应少，值得临床推广。

Abstract:
ObjectiveTo investigate the efficacy of Ginkgo Folium extract combined with hyperbaric oxygen in the treatment of Alzheimer's disease in the elderly.
MethodsNinety-eight patients with Alzheimer's disease were randomly divided into the control group and observation group(49 cases in each group).The control group was treated with Ginkgo Folium extract, and the observation group was treated with Ginkgo Folium extract combined with hyperbaric oxygen therapy.The clinical efficacy, serum index and incidence rate of adverse reactions were compared between the two groups.
ResultsAfter treatment, the MMSE score and ADL score in observation group were higher than those in control group, while the ADAS-Cog score in observation group was lower than that in control group(P < 0.01).After treatment, the levels of SOD, GSH-Px and TGF-β1 in observation group were higher than those in control group, and the levels of MDA and IL-1β were lower than those in the control group(P < 0.01).The differences of the incidence rates of fatigue, nausea, dizziness, insomnia and rash between the two groups were not statistically significant(P>0.05).
ConclusionsGinkgo Folium extract combined with hyperbaric oxygen in the treatment of elderly Alzheimer's disease can effectively improve clinical efficacy and serum related indicators, and has fewer adverse reactions, which is worthy of clinical promotion.

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