丹红注射液联合阿托伐他汀钙对急性脑梗死病人血清胱抑素C、同型半胱氨酸及尿酸的影响

宋志友; 李从圣; 孟令毅; 胡承志; 群森

doi:10.13898/j.cnki.issn.1000-2200.2022.01.008

丹红注射液联合阿托伐他汀钙对急性脑梗死病人血清胱抑素C、同型半胱氨酸及尿酸的影响

Effect of Danhong injection combined with atorvastatin calcium on serum cystatin C, homocysteine and uric acid in patients with acute cerebral infarction

摘要

摘要:
目的探讨丹红注射液联合阿托伐他汀钙对急性脑梗死（ACI）病人血清胱抑素C（Cys-C）、同型半胱胺酸（Hcy）、血尿酸（SUA）水平的影响。
方法选择ACI病人93例，采用随机数字表法分为观察组（47例）和对照组（46例）。对照组给予阿托伐他汀钙治疗，观察组给予丹红注射液联合阿托伐他汀钙治疗。治疗14 d，比较2组美国国立卫生研究院卒中量表（NIHSS）减分率、临床疗效、实验室检测指标（Cys-C、Hcy、SUA）水平和不良反应发生率。
结果治疗后2组NIHSS评分均明显低于治疗前（P < 0.01）；观察组病人NIHSS评分明显低于对照组（P < 0.01），NIHSS减分率、有效率均高于对照组（P < 0.05）。治疗后2组Cys-C、Hcy、SUA水平均明显低于治疗前（P < 0.01），且观察组Cys-C、Hcy、SUA含量均低于对照组（P < 0.05）。观察组病人不良反应发生率为6.38%（3/47），低于对照组的21.74%（10/46）（P < 0.05）。
结论丹红注射液联合阿托伐他汀钙有助于缓解ACI病人神经功能缺损程度，提高临床疗效，减少不良反应，可能与降低血清Cys-C、Hcy、SUA含量有关。

Abstract:
ObjectiveTo investigate the effects of Danhong injection combined with atorvastatin calcium on serum cystatin C(Cys-C), homocysteine(Hcy) and serum uric acid(SUA) levels in patients with acute cerebral infarction(ACI).
MethodsA total of 93 ACI patients were selected and divided into observation group(47 cases) and control group(46 cases) by random number table method.The control group was treated with atorvastatin calcium, and the observation group was treated with Danhong injection combined with atorvastatin calcium.After 14 days of treatment, the reduction rate of the National Institutes of Health stroke scale(NIHSS) score, clinical efficacy, levels of laboratory test indicators(including Cys-C, Hcy and SUA) and the incidence of adverse reactions were compared between the two groups.
ResultsAfter treatment, the NIHSS scores in the two groups were significantly lower than those before treatment(P < 0.01);the NIHSS score in observation group were significantly lower than that in control group(P < 0.01), and the reduction rate of NIHSS score and effective rate were higher than those in control group(P < 0.05).After treatment, the levels of Cys-C, Hcy, and SUA in the two groups were significantly lower than those before treatment(P < 0.01), and the levels of Cys-C, Hcy, and SUA in observation group were lower than those in control group(P < 0.05).The incidence of adverse reactions in observation group(6.38%, 3/47) was lower than that in control group(21.74%, 10/46)(P < 0.05).
ConclusionsDanhong injection combined with atorvastatin calcium can be helpful to relieve neurological deficits in patients with ACI, improve clinical efficacy, and reduce adverse reactions, which may be related to the reduction of serum Cys-C, Hcy, SUA levels.

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