ObjectiveTo study the effects of ateplase combined with adebenquinone on the recovery, nerve injury index and TXB2 level in acute cerebral infarction(ACI) patients.

MethodsOne hundred and twenty patients with ACI were randomly divided into the observation group and control group(60 cases in each group).The observation group was treated with the ateprase combined with edebenzoquinone, while the control group was treated with ateprase for 2 weeks.The therapeutic effects, nerve function, prognosis, coagulation function and TXB2 level were compared between two groups.

ResultsThe total effective rate in observation group(83.33%) was significantly higher than that in control group(55.00%) (P < 0.01).The differences of the CSS score, NIHSS score and Barthel index between two groups before treatment were not statistically significant(P>0.05).After treatment, the CSS score and NIHSS score in observation group were significantly lower than those in control group, and the Barthel index in observation group was significantly higher than that in control group(P < 0.01).The number of patients with modified Rankin scale score >2 points in observation group was significantly lower than that in control group(P < 0.01).There was no statistical significance in the D-dimer, TXB2 and thrombin time, prothrombin time and ctivated partial thrombin time between two groups before treatment(P>0.05).After treatment, the levels of D-dimer and TXB2 in observation group were significantly lower than those in control group(P < 0.01), and the levels of thrombin time, prothrombin time and activated partial thrombin time in observation group were higher than those in control group(P < 0.05 to P < 0.01).

ConclusionsThe combination of alteplase and edibenzoquinone in the treatment of ACI can better recover the patient's neurological function, improve the blood coagulation index and TXB2 level, and is worthy of clinical promotion.