ObjectiveTo analyze the efficacy and long-term follow-up results of the drug triple thrapy in the treatment of bronchopulmonary dysplasia in very low birth weight infants.

MethodsThe clinical data of 244 children with very low birth weight(body mass < 1 500 g) complicated with bronchopulmonary dysplasia were retrospectively analyzed.All patients were treated with invasive mechanical ventilation through endotracheal intubation at admission.One hundred and twenty children treated with budesonide combined with pulmonary surfactant and 124 children treated with budesonide pulmonary surfactant, combined with vitamin A were divided into the control group and observation group, respectively.The differences of the therapeutic effect, revisit rate, recovery time of respiratory capacity, blood gas analysis and oxygenation index and complications during treatment were compared between two groups.The patients were followed up for 2 years, and the lung function in two groups was analyzed at 1 and 2 years of age.

ResultsThe total effective rate in the observation group was 91.94%(114/124), which was higher than that in control group(78.33%, 94/120)(P < 0.01);the rate of revisiting in the observation group was 7.26%(9/124), which was lower than 18.33%(22/120) of the control group(P < 0.01), and the total incidence rate of complications during treatment in the observation group was 3.23%(4/124), which was lower than 15.00%(18/120) of the control group(P < 0.01).The time of oxygen inhalation, mechanical ventilation and hospital stay in observation group were shorter than those in control group(P < 0.01), and the respiratory rate in observation group was lower than that in control group(P < 0.01).After two courses of treatment, the arterial partial pressure of oxygen, pH value and oxygenation index in observation group were higher than those in control group(P < 0.01), and the arterial partial pressure of carbon dioxide in observation group was lower than that in control group(P < 0.01).The inspiratory time, peak volume ratio and peak time ratio in observation group were higher than those in control group at 1 and 2 years old(P < 0.01), while the expiratory time in observation group was lower than that in control group(P < 0.01).

ConclusionsThe effects of drug triple therapy in the treatment of children with very low birth weight complicated bronchopulmonary dysplasia is significant, which can adjust the blood gas analysis and oxygenation index, promote the rapid recovery of respiratory capacity, improve the prognostic pulmonary function indexes, and have fewer complications and high safety during the treatment.