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    杨国娟, 崔韬. 肌萎缩侧索硬化病人CCL2和IL-6的表达水平与认知功能的相关性研究[J]. 蚌埠医科大学学报, 2022, 47(3): 309-312. DOI: 10.13898/j.cnki.issn.1000-2200.2022.03.008
    引用本文: 杨国娟, 崔韬. 肌萎缩侧索硬化病人CCL2和IL-6的表达水平与认知功能的相关性研究[J]. 蚌埠医科大学学报, 2022, 47(3): 309-312. DOI: 10.13898/j.cnki.issn.1000-2200.2022.03.008
    shu
    YANG Guo-juan, CUI Tao. Study on the correlation of the levels of CCL2 and IL-6 with cognitive function in amyotrophic lateral sclerosis patients[J]. Journal of Bengbu Medical University, 2022, 47(3): 309-312. DOI: 10.13898/j.cnki.issn.1000-2200.2022.03.008
    Citation: YANG Guo-juan, CUI Tao. Study on the correlation of the levels of CCL2 and IL-6 with cognitive function in amyotrophic lateral sclerosis patients[J]. Journal of Bengbu Medical University, 2022, 47(3): 309-312. DOI: 10.13898/j.cnki.issn.1000-2200.2022.03.008
    shu

    肌萎缩侧索硬化病人CCL2和IL-6的表达水平与认知功能的相关性研究

    Study on the correlation of the levels of CCL2 and IL-6 with cognitive function in amyotrophic lateral sclerosis patients

      摘要
    • 摘要:
      目的检测肌萎缩侧索硬化病人的外周血趋化因子配体2(chemokine ligand-2，CCL2)和白细胞介素6(interleukin 6，IL-6)的表达水平及与认知功能评分的相关性。
      方法选择肌萎缩侧索硬化病人32例(观察组)和肌肉病病人(对照组)20例，ELISA法检测血浆CCL2和IL-6的水平，利用简易智能量表(Mini-mental State Examination，MMSE)和韦氏记忆量表(Wechsler Intelligence Scale，WMS)评估病人的认知功能情况。
      结果2组病人的年龄、性别和教育程度差异均无统计学意义(P>0.05)。ELISA检测结果显示，观察组CCL2和IL-6水平均明显高于对照组(P < 0.01)。观察组MMSE评分明显低于对照组(P < 0.01)；观察组WMS中记忆商、长时记忆、短时记忆和瞬时记忆得分均低于对照组(P < 0.05~P < 0.01)。观察组CCL2与MMSE评分和WMS评分均呈负相关关系(P < 0.05)。
      结论肌萎缩侧索硬化病人血浆CCL2和IL-6较肌肉病病人增加，存在认知功能下降；外周血CCL2水平与认知功能障碍有关。

       

      Abstract:
      ObjectiveTo detect the levels of chemokine ligand-2(CCL2) and interleukin 6(IL-6) in peripheral blood in amyotrophic lateral sclerosis(ALS) patients, and analyze the correlation of the levels of CCL2 and IL-6 with cognitive function.
      MethodsThirty-two ALS patients and 20 myopathy patients were divided into the observation group and control group, respectively.The plasma levels of CCL2 and IL-6 in two groups were detected using ELISA, and the cognitive function in two groups were evaluated using Mini-mental State Examination(MMSE) and Wechsler Intelligence Scale(WMS).
      ResultsThe differences of the age, gender and education level between two groups were not statistically significant(P>0.05).The results of ELISA showed that the levels of CCL2 and IL-6 in observation group were higher than those in control group(P < 0.01).The MMSE score in observation group was lower than that in control group(P < 0.01).The scores of the memory quotient, long-term memory, short-term and transient memory in observation group were lower than those in control group(P < 0.05 to P < 0.01).The level of CCL2 was negatively correlated with the MMSE score and WMS score(P < 0.05).
      ConclusionsCompared with the myopathy patients, the plasma levels of CCL2 and IL-6 are upregulated, and the cognitive function decrease in ALS patients.The level of CCL2 in peripheral blood is negatively correlated to the cognitive function of patients.

       

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