肿瘤坏死因子受体相关因子4在结直肠癌中的表达及临床意义

陈广业; 杨清

doi:10.13898/j.cnki.issn.1000-2200.2022.03.012

肿瘤坏死因子受体相关因子4在结直肠癌中的表达及临床意义

陈广业,
杨清

Expression and clinical significance of tumor necrosis factor receptor-related factor 4 in colorectal cancer

摘要

摘要:
目的探讨肿瘤坏死因子受体相关因子4(tumor necrosis factor receptor-associated factor 4，TRAF4)在结肠癌组织中的表达及临床意义。
方法用免疫组织化学染色法检测112例结肠癌组织标本及其配对的癌旁组织标本中TRAF4的表达。根据染色结果将病人分为高表达组和低表达组，比较2组临床病理学资料和生存预后。生存分析用Kaplan-Meier法，组间生存率比较用Log-rank检验；用COX比例风险回归模型分析结肠癌病人预后的影响因素。
结果TRAF4主要表达于细胞核中。结肠癌组织中TRAF4高表达率为73.21%(82/112)，明显高于癌旁组织的33.04%(37/112)(P < 0.01)。低分化结肠癌病人的TRAF4高表达率明显高于高分化病人(P < 0.01)，T分期越高，TRAF4高表达率越大(P < 0.01)，M1期结肠癌病人的TRAF4高表达率明显高于M0期病人(P < 0.01)。分化程度、T分期、N分期、M分期和TRAF4均为结肠癌病人总体生存时间的独立影响因素(P < 0.05)，分化程度、N分期、M分期和TRAF4均为结肠癌病人无进展生存时间的独立影响因素(P < 0.05)。高表达组总体生存率和无进展生存率分别为64.29%和69.64%，均低于低表达组的82.43%和90.18%(P < 0.05)。高表达组中位生存时间和无进展生存时间分别为70.92个月和72.55个月，均低于低表达组的84.81个月和89.66个月(P < 0.05)。
结论TRAF4与结肠癌分化程度、T分期、M分期有关，TRAF4高表达往往预示着结肠癌的不良生存预后。

Abstract:
ObjectiveTo investigate the expression levels and clinical significance of tumor necrosis factor receptor-associated factor 4(TRAF4) in colon cancer.
MethodsThe expression levels of TRAF4 in 112 colon cancer tissue specimens and their matched adjacent tissue specimens were detected using the immunohistochemical staining.According to the staining results, the patients were divided into the high expression group and low expression group, and the clinical pathology data and survival prognosis between two groups were compared.The Kaplan-Meier method was used for survival analysis, and the Log-rank test was used to compare the survival rates between groups.The COX proportional hazards regression model was used to analyze the prognostic factors of colon cancer patients.
ResultsTRAF4 was mainly expressed in the nucleus.The high expression rate of TRAF4 in colon cancer tissue was 73.21%(82/112), which was significantly higher than that in the adjacent tissues33.04%(37/112)(P < 0.01).The high expression rate of TRAF4 in patients with poorly differentiated colon cancer was significantly higher than that in patients with well differentiated patients(P < 0.01).The higher the T stage, the greater the high expression rate of TRAF4 was(P < 0.01).The high expression rate of TRAF4 in patients with stage M1 colon cancer was significantly higher than that in patients with M0 stage(P < 0.01).The degree of differentiation, T stage, N stage, M stage and TRAF4 were the independent factors affecting the overall survival time of colon cancer patients(P < 0.05), and the degree of differentiation, N stage, M stage and TRAF4 were the independent factors influencing the progression-free survival time of colon cancer patients(P < 0.05).The overall survival rate and progression-free survival rate in high expression group were 64.29% and 69.64%, respectively, which were lower than those in low expression group(82.43% and 90.18%)(P < 0.05).The median survival time and progression-free survival time in the high expression group were 70.92 months and 72.55 months, respectively, which were lower than those in low expression group(84.81 months and 89.66 months)(P < 0.05).
ConclusionsTRAF4 is related to the degree of differentiation, T stage and M stage of colon cancer, and the high expression of TRAF4 predicts the poor survival prognosis of colon cancer.

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