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    李文娟, 李帅. 丁苯酞注射液治疗急性脑梗死疗效及其对病人血清NT-proBNP和Hcy水平影响[J]. 蚌埠医科大学学报, 2022, 47(3): 345-348. DOI: 10.13898/j.cnki.issn.1000-2200.2022.03.018
    引用本文: 李文娟, 李帅. 丁苯酞注射液治疗急性脑梗死疗效及其对病人血清NT-proBNP和Hcy水平影响[J]. 蚌埠医科大学学报, 2022, 47(3): 345-348. DOI: 10.13898/j.cnki.issn.1000-2200.2022.03.018
    shu
    LI Wen-juan, LI Shuai. Effect of butylphthalide injection on acute cerebral infarction and its influence on serum N-terminal pro-B-type natriuretic peptide and homocysteine level[J]. Journal of Bengbu Medical University, 2022, 47(3): 345-348. DOI: 10.13898/j.cnki.issn.1000-2200.2022.03.018
    Citation: LI Wen-juan, LI Shuai. Effect of butylphthalide injection on acute cerebral infarction and its influence on serum N-terminal pro-B-type natriuretic peptide and homocysteine level[J]. Journal of Bengbu Medical University, 2022, 47(3): 345-348. DOI: 10.13898/j.cnki.issn.1000-2200.2022.03.018
    shu

    丁苯酞注射液治疗急性脑梗死疗效及其对病人血清NT-proBNP和Hcy水平影响

    Effect of butylphthalide injection on acute cerebral infarction and its influence on serum N-terminal pro-B-type natriuretic peptide and homocysteine level

      摘要
    • 摘要:
      目的观察丁苯酞注射液治疗急性脑梗死的疗效，探讨其对病人血清N末端B型钠尿肽前体(NT-proBNP)和同型半胱氨酸(Hcy)水平的影响。
      方法急性脑梗死病人70例，随机分为观察组和对照组，各35例。2组病人均给予常规治疗，观察组在此基础上给予丁苯酞氯化钠注射液静脉滴注，每次100 mL，每天2次，持续10~14 d。比较2组病人的临床疗效，测定治疗前后血清NT-proBNP、Hcy水平，并于治疗前后分别采用美国国立卫生研究院卒中量表(NIHSS)对2组病人神经功能缺损进行评分，采用改良Rankin量表(mRS)评估病人神经功能状态。
      结果观察组病人治疗总有效率为94.29%(33/35)，明显优于对照组的71.43%(25/35)(P < 0.01)。治疗前，2组病人NIHSS、mRS评分和血清NT-proBNP、Hcy水平差异均无统计学意义(P > 0.05)；治疗后，观察组病人NIHSS、mRS评分和NT-proBNP、Hcy水平均较治疗前降低(P < 0.05)，且观察组病人NIHSS评分和NT-proBNP、Hcy水平均明显低于对照组治疗后(P < 0.01)。
      结论丁苯酞注射液可改善急性脑梗死病人神经功能缺损，降低其血清NT-proBNP和Hcy水平。

       

      Abstract:
      ObjectiveTo observe the curative effect of butylphthalide injection in the treatment of acute cerebral infarction, and to explore its influence on the levels of serum N-terminal pro-B-type natriuretic peptide(NT-proBNP) and homocysteine(Hcy).
      MethodsA total of 70 patients with acute cerebral infarction were randomly divided into observation group and control group, 35 cases in each group. The patients were given conventional treatment, and the observation group was additionally given butylphthalide sodium chloride injection 100 mL each time, intravenous drip, twice a day, continuous injection for 10-14 days. The clinical efficacies of two groups were compared, and the levels of serum NT-proBNP and Hcy were measured before and after treatment. The neurological deficits of the two groups were scored by National Institutes of Health stroke scale(NIHSS) before and after treatment, and the neurological status of the patients was evaluated by modified Rankin scale(mRS).
      ResultsThe total treatment efficiency in the observation group was 94.29%(33/35), which was significantly better than 71.43%(25/35) in the control group(P < 0.01). Before treatment, there was no significant difference in NIHSS score, mRS score and serum NT-proBNP and Hcy levels between the two groups(P > 0.05). After treatment, NIHSS score, mRS score, NT-proBNP and Hcy levels in the observation group were lower than those before treatment(P < 0.05), while NIHSS score, NT-proBNP and Hcy levels in the observation group were significantly lower than those in the control group(P < 0.01).
      ConclusionsButylphthalide injection can improve the neurological deficit of acute cerebral infarction and reduce the serum NT-proBNP and Hcy levels.

       

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