生长激素联合拮抗剂方案对卵巢低反应人群IVF-ET妊娠结局的作用

曾彬; 于婉莹; 梁雨; 苏兴

doi:10.13898/j.cnki.issn.1000-2200.2022.03.021

生长激素联合拮抗剂方案对卵巢低反应人群IVF-ET妊娠结局的作用

Effect of growth hormone combined with antagonist regimen on pregnancy outcomes in IVF-ET patients with low ovarian response

摘要

摘要:
目的探讨卵巢低反应(poor ovarian response, POR)病人接受体外受精-胚胎移植(in vitro fertilization-embryo transfer，IVF-ET)治疗时，应用生长激素(growth hormone, GH)联合拮抗剂方案对妊娠结局的影响。
方法回顾性分析接受IVF-ET治疗并采用拮抗剂方案的POR病人176例临床资料，按照是否应用GH分为应用GH组(GH⁺组)84例和不应用GH组(GH^-组)92例。比较2组获卵数、MⅡ卵率、正常受精率、第3天可移植胚胎率、第3天优质胚胎率、囊胚形成率、优质囊胚率、临床妊娠率、种植率等指标。
结果GH⁺组获卵数、第3天可移植胚胎率、囊胚形成率、临床妊娠率、种植率均高于GH^-组(P < 0.05~P < 0.01)，2组MⅡ卵率、正常受精率、第3天优质胚胎率、优质囊胚率差异均无统计学意义(P > 0.05)。
结论GH联合拮抗剂方案有助于改善POR人群IVF-ET妊娠结局。

Abstract:
ObjectiveTo explore the effects of the growth hormone(GH) combined with antagonist regimen on pregnancy outcome in poor ovarian response(POR) patients treated with fertilization-embryo transfer(IVF-ET) in vitro.
MethodsThe clinical data of 176 POR patients treated with IVF-ET were retrospectively analyzed, and the patients were divided into the GH group(GH⁺ group, 84 cases) and non-GH group(GH^- group, 92 cases) according to whether GH was used or not. The egg number, MⅡ egg rate, normal fertilization rate, day 3 transferable embryo rate, day 3 high quality embryo rate, blastocyst formation rate, high quality blastocyst rate, clinical pregnancy rate and implantation rate were compared between two groups.
ResultsThe egg number, daybryo rate, blastocyst formation rate, clinical pregnancy rate and implantation rate in GH⁺ group were higher than those in GH^- group(P < 0.05 to P < 0.01).The differences of MⅡ egg rate, normal fertilization rate, high quality embryo rate on day 3 and high quality blastocyst rate between two groups were not statistically significant(P > 0.05).
ConclusionsThe GH combined antagonist regimen is helpful for improving IVF-ET pregnancy outcomes in the POR patients.

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