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    苏智祥, 于滨, 魏晓辉, 张燕军. 弥漫性大B细胞淋巴瘤组织中IP-10及受体CXCR3表达与细胞增殖、侵袭、耐药蛋白表达的相关性[J]. 蚌埠医科大学学报, 2022, 47(4): 487-490. DOI: 10.13898/j.cnki.issn.1000-2200.2022.04.015
    引用本文: 苏智祥, 于滨, 魏晓辉, 张燕军. 弥漫性大B细胞淋巴瘤组织中IP-10及受体CXCR3表达与细胞增殖、侵袭、耐药蛋白表达的相关性[J]. 蚌埠医科大学学报, 2022, 47(4): 487-490. DOI: 10.13898/j.cnki.issn.1000-2200.2022.04.015
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    SU Zhi-xiang, YU Bin, WEI Xiao-hui, ZHANG Yan-jun. Study on the correlation between the expression levels of IP-10 and CXCR3 in diffuse large B-cell lymphoma tissue, and cell proliferation, invasion and drug resistance proteins expression[J]. Journal of Bengbu Medical University, 2022, 47(4): 487-490. DOI: 10.13898/j.cnki.issn.1000-2200.2022.04.015
    Citation: SU Zhi-xiang, YU Bin, WEI Xiao-hui, ZHANG Yan-jun. Study on the correlation between the expression levels of IP-10 and CXCR3 in diffuse large B-cell lymphoma tissue, and cell proliferation, invasion and drug resistance proteins expression[J]. Journal of Bengbu Medical University, 2022, 47(4): 487-490. DOI: 10.13898/j.cnki.issn.1000-2200.2022.04.015
    shu

    弥漫性大B细胞淋巴瘤组织中IP-10及受体CXCR3表达与细胞增殖、侵袭、耐药蛋白表达的相关性

    Study on the correlation between the expression levels of IP-10 and CXCR3 in diffuse large B-cell lymphoma tissue, and cell proliferation, invasion and drug resistance proteins expression

      摘要
    • 摘要:
      目的研究弥漫性大B细胞淋巴瘤(DLBCL)病人组织中重组人干扰素诱导蛋白-10(IP-10)及受体CXC亚族趋化因子受体3(CXCR3)的表达及与细胞增殖、侵袭、耐药蛋白表达的相关性。
      方法选取60例DLBCL病人资料，30例反应性淋巴结增生病人为对照组，比较2组IP-10、CXCR3、细胞增殖指标Ki67、增殖细胞核抗原(PCNA)、白细胞分化抗原44变异体6(CD44V6)、基质金属蛋白酶-9(MMP-9)、P-糖蛋白(P-gp)、多药耐药相关蛋白1(MRP1)的表达。
      结果DLBCL组中IP-10、CXCR3、Ki67、PCNA、CD44V6、MMP-9、P-gp、MRP1的表达明显高于对照组(P < 0.01)，在DLBCL组织中，IP-10、CXCR3的表达与细胞增殖相关蛋白(Ki67、PCNA)及肿瘤侵袭相关蛋白(PCNA、CD44V6)具有相关性(P < 0.05~P < 0.01)，而与细胞耐药相关蛋白(P-gp、MRP1)表达无相关性(P>0.05)。
      结论在DLBCL组织中IP-10及受体CXCR3表达明显增高，IP-10及受体CXCR3表达可能增加了肿瘤细胞的增殖及侵袭性，与肿瘤细胞的耐药性可能无关。

       

      Abstract:
      ObjectiveTo study the correlation between the expression levels of recombinant human interferon inducible protein-10(IP-10) and CXC subfamily chemokine receptor 3(CXCR3) in diffuse large B-cell lymphoma(DLBCL) tissue, and cell proliferation, invasion and drug resistance proteins expression.
      MethodsSixty DLBCL patients and 30 patients with reactive lymph node hyperplasia were divided into the DLBCL group and control group, respectively.The levels of IP-10, CXCR3, cell proliferation indicator Ki67, proliferating cell nuclear antigen(PCNA), leukocyte differentiation antigen 44V6(CD44V6), matrix metalloproteinase-9(MMP-9), P-glycoprotein(P-gp) and multidrug resistance associated protein 1(MRP1) were compared between two groups.
      ResultsThe expression levels of IP-10, CXCR3, Ki67, PCNA, CD44V6, MMP-9, P-gp and MRP1 in DLBCL group were significantly higher than those in control group(P < 0.01).In DLBCL group, the expression levels of IP-10 and CXCR3 were correlated with the expression of cell proliferation-related proteins(Ki67 and PCNA) and tumor invasion-related proteins(PCNA and CD44V6)(P < 0.05 to P < 0.01), and not correlated with the expression of cell drug-resistance-related proteins(P-gp and MRP1)(P>0.05).
      ConclusionsIn DLBCL, the expression levels of IP-10 and CXCR3 increase significantly.The expression of IP-10 and CXCR3 may increase the proliferation and invasion of tumor cells, which may not be related to the drug resistance of tumor cells.

       

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