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    甲状腺激素、性激素、C反应蛋白与男性精神分裂症病人攻击行为的相关性分析

    Correlation analysis of thyroid hormone, sex hormone, C-reactive protein and aggressive behavior in male patients with schizophrenia

      摘要
    • 摘要:
      目的 探讨甲状腺激素、性激素、C反应蛋白(CRP)对男性精神分裂症病人攻击行为的影响。
      方法 选取173例男性精神分裂症病人，按照外显攻击行为量表(MOAS)评分分为观察组(MOAS评分≥5分)88例和对照组(MOAS评分 < 5分)85例。比较2组病人外周血三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、睾酮(TESTO)、雌二醇(E2)、CRP水平。分析观察组病人甲状腺激素、性激素、CRP与攻击行为的相关性。
      结果 2组FT3、TSH水平差异均无统计学意义(P>0.05)，观察组病人T3、T4、FT4水平均高于对照组(P < 0.05~P < 0.01)。2组E2水平差异无统计学意义(P>0.05)，观察组病人TESTO、CRP水平均高于对照组(P < 0.01和P < 0.05)。Pearson相关分析结果显示，观察组T4、FT4、TESTO水平与MOAS量表总分均呈明显正相关关系(r=0.341、0.274、0.262，P < 0.01)。
      结论 伴攻击行为的男性精神分裂症病人外周血T3、T4、FT4、TESTO、CRP水平升高，其T4、FT4、TESTO水平与攻击行为呈明显正相关关系。T3、T4、FT4、TESTO、CRP水平检测对临床评估和预防冲动攻击性具有一定的指导意义。

       

      Abstract:
      Objective To investigate the effects of thyroid hormone, sex hormone and C-reactive protein(CRP) on aggressive behavior in male patients with schizophrenia.
      Methods A total of 173 male patients with schizophrenia were selected and divided into the observation groupmodified overt aggression scale(MOAS) score ≥5 points, n=88 and control group(MOAS score < 5 points, n=85) according to the MOAS score.The levels of triiodothyronine(T3), thyroxine(T4), free triiodothyronine(FT3), free thyroxine(FT4), thyroid stimulating hormone(TSH), testosterone(TESTO) and estradiol(E2) in the peripheral blood of patients in the two groups were compared.The correlation between thyroid hormone, sex hormone, CRP and aggressive behavior in the observation group was analyzed.
      Results There was no significant difference in the levels of FT3 and TSH between the two groups(P>0.05), and the levels of T3, T4 and FT4 in the observation group were higher than those in the control group(P < 0.05 to P < 0.01).There was no significant difference in the level of E2 between the two groups(P>0.05), and the levels of TESTO and CRP in the observation group were higher than those in the control group(P < 0.01 and P < 0.05).Pearson correlation analysis showed that the levels of T4, FT4 and TESTO in the observation group were significantly positively correlated with the total MOAS score(r=0.341, 0.274, 0.262, P < 0.01).
      Conclusions The levels of T3, T4, FT4, TESTO and CRP in the peripheral blood of male schizophrenia patients with aggressive behavior increase, and the levels of T4, FT4 and TESTO are significantly positively correlated with aggressive behavior.The detection of T3, T4, FT4, TESTO and CRP levels has certain guiding significances for clinical evaluation and prevention of impulsive aggression.

       

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